Evaluation of variability in cell-free DNA extraction efficiency from plasma and urine and spike-in normalization

Evaluation of variability in cell-free DNA extraction efficiency from plasma and urine and spike-in normalization

Abstract Cell-free DNA (cfDNA) is a promising new biomarker for clinical use in e.g. oncology and transplantation medicine. Urinary cfDNA is also gaining interest as a non-invasive biomarker. However, cfDNA extraction is not standardised, leading to a variety of different methods being used with var...

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Bibliographic Details
Main Authors: Fanny Sandberg, Nicholas Kueng, Carlo Rodolfo Largiadèr, Ursula Amstutz
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cell-Free DNA
Extraction efficiency
Spike-in
Liquid biopsy
Pre-analytics
Online Access:https://doi.org/10.1038/s41598-025-06563-z
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