Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model
Skin wounds are a public health concern due to limited effective natural remedies. This study aimed to develop and evaluate a novel wound dressing hydrogel composed of polyacrylic acid (PAA) and xanthan gum (XG) using a rat excisional injury model. The hydrogel was synthesized via free radical polym...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025019243 |
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| author | Seyyedeh Sahra Mirmasoudi Zahra Pourmohammadi-Bejarpasi Mohsen Shahrousvand Mehryar Habibi Roudkenar |
| author_facet | Seyyedeh Sahra Mirmasoudi Zahra Pourmohammadi-Bejarpasi Mohsen Shahrousvand Mehryar Habibi Roudkenar |
| author_sort | Seyyedeh Sahra Mirmasoudi |
| collection | DOAJ |
| description | Skin wounds are a public health concern due to limited effective natural remedies. This study aimed to develop and evaluate a novel wound dressing hydrogel composed of polyacrylic acid (PAA) and xanthan gum (XG) using a rat excisional injury model. The hydrogel was synthesized via free radical polymerization, employing potassium persulfate (KPS) as an initiator and N,N-methylene bisacrylamide (MBA) as a crosslinker. Morphological characterization was performed using Scanning Electron Microscopy (SEM), Fourier-transform Infrared Spectroscopy (FTIR), and Thermogravimetric Analysis (TGA). Swelling and deswelling tests identified the optimal formulation containing 1 % XG, which exhibited enhanced swelling ratios, mechanical strength, and controlled release properties. In vivo studies demonstrated that this hydrogel formulation significantly improved wound contraction and healing rates in comparison to controls, showing excellent biocompatibility and non-toxicity. These results suggest that combining natural biopolymers like xanthan gum with synthetic polymers offers a promising new approach for wound care. Further studies, including clinical trials, are warranted to validate the therapeutic potential of this xanthan gum-based hydrogel dressing. |
| format | Article |
| id | doaj-art-a1be24eed6d54069b0bc5a972f3d07b5 |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a1be24eed6d54069b0bc5a972f3d07b52025-08-20T03:12:24ZengElsevierHeliyon2405-84402025-07-011112e4353810.1016/j.heliyon.2025.e43538Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury modelSeyyedeh Sahra Mirmasoudi0Zahra Pourmohammadi-Bejarpasi1Mohsen Shahrousvand2Mehryar Habibi Roudkenar3Burn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, IranBurn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, IranCaspian Faculty of Engineering, College of Engineering, University of Tehran, Guilan, Rezvanshar, IranBurn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, Iran; Corresponding author.Skin wounds are a public health concern due to limited effective natural remedies. This study aimed to develop and evaluate a novel wound dressing hydrogel composed of polyacrylic acid (PAA) and xanthan gum (XG) using a rat excisional injury model. The hydrogel was synthesized via free radical polymerization, employing potassium persulfate (KPS) as an initiator and N,N-methylene bisacrylamide (MBA) as a crosslinker. Morphological characterization was performed using Scanning Electron Microscopy (SEM), Fourier-transform Infrared Spectroscopy (FTIR), and Thermogravimetric Analysis (TGA). Swelling and deswelling tests identified the optimal formulation containing 1 % XG, which exhibited enhanced swelling ratios, mechanical strength, and controlled release properties. In vivo studies demonstrated that this hydrogel formulation significantly improved wound contraction and healing rates in comparison to controls, showing excellent biocompatibility and non-toxicity. These results suggest that combining natural biopolymers like xanthan gum with synthetic polymers offers a promising new approach for wound care. Further studies, including clinical trials, are warranted to validate the therapeutic potential of this xanthan gum-based hydrogel dressing.http://www.sciencedirect.com/science/article/pii/S2405844025019243Wound dressingXanthan gumPolyacrylic acidHydrogelRat modelExcisional injury |
| spellingShingle | Seyyedeh Sahra Mirmasoudi Zahra Pourmohammadi-Bejarpasi Mohsen Shahrousvand Mehryar Habibi Roudkenar Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model Heliyon Wound dressing Xanthan gum Polyacrylic acid Hydrogel Rat model Excisional injury |
| title | Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| title_full | Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| title_fullStr | Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| title_full_unstemmed | Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| title_short | Xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| title_sort | xanthan gum hydrogel wound dressing enhances wound healing in a rat excisional injury model |
| topic | Wound dressing Xanthan gum Polyacrylic acid Hydrogel Rat model Excisional injury |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025019243 |
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