Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis
Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/2503378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169447749255168 |
|---|---|
| author | Rodolfo Kölliker Frers Matilde Otero-Losada Tamara Kobiec María Inés Herrera Lucas Udovin Carlos F. Kusnier Francisco Capani |
| author_facet | Rodolfo Kölliker Frers Matilde Otero-Losada Tamara Kobiec María Inés Herrera Lucas Udovin Carlos F. Kusnier Francisco Capani |
| author_sort | Rodolfo Kölliker Frers |
| collection | DOAJ |
| description | Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses’ diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response. |
| format | Article |
| id | doaj-art-a1bc3124daa54dce994ffb77b020ec52 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a1bc3124daa54dce994ffb77b020ec522025-08-20T02:20:44ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/25033782503378Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern PsoriasisRodolfo Kölliker Frers0Matilde Otero-Losada1Tamara Kobiec2María Inés Herrera3Lucas Udovin4Carlos F. Kusnier5Francisco Capani6Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS-UAI.CONICET, ArgentinaAutoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses’ diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response.http://dx.doi.org/10.1155/2021/2503378 |
| spellingShingle | Rodolfo Kölliker Frers Matilde Otero-Losada Tamara Kobiec María Inés Herrera Lucas Udovin Carlos F. Kusnier Francisco Capani Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis Mediators of Inflammation |
| title | Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis |
| title_full | Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis |
| title_fullStr | Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis |
| title_full_unstemmed | Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis |
| title_short | Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis |
| title_sort | interleukin 1 links autoimmune and autoinflammatory pathophysiology in mixed pattern psoriasis |
| url | http://dx.doi.org/10.1155/2021/2503378 |
| work_keys_str_mv | AT rodolfokollikerfrers interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT matildeoterolosada interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT tamarakobiec interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT mariainesherrera interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT lucasudovin interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT carlosfkusnier interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis AT franciscocapani interleukin1linksautoimmuneandautoinflammatorypathophysiologyinmixedpatternpsoriasis |