A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment
Abstract Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the pharmacological properties of Schisandra chinensis lignans, including their antioxidant, a...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01096-z |
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| author | Danushiya Ehambarampillai Murphy Lam Yim Wan |
| author_facet | Danushiya Ehambarampillai Murphy Lam Yim Wan |
| author_sort | Danushiya Ehambarampillai |
| collection | DOAJ |
| description | Abstract Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the pharmacological properties of Schisandra chinensis lignans, including their antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, antibacterial/viral, antidiabetic and anticancer effects. Their multifaceted mechanisms of action hold promise for therapeutic areas such as cancer, neurodegenerative diseases and metabolic disorders, aligning with urgent clinical needs. Additionally, this review explores the pharmacokinetics of these bioactive compounds, highlighting challenges in their absorption, distribution, metabolism and excretion, which impact their bioavailability. Recent advancements in drug delivery systems are discussed, highlighting their potential to enhance therapeutic efficacy in clinical settings. Furthermore, the synergistic effects of combining these lignans with other therapeutic agents are considered a strategy to increase their efficacy. Future research is imperative to identify additional active components and elucidate novel mechanisms of action, paving the way for expanded therapeutic applications and unlocking the full clinical potential of Schisandra chinensis in disease prevention and treatment. |
| format | Article |
| id | doaj-art-a1b6439841804ee19e355ac16fbf8dd8 |
| institution | DOAJ |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-a1b6439841804ee19e355ac16fbf8dd82025-08-20T03:06:55ZengBMCChinese Medicine1749-85462025-04-0120113410.1186/s13020-025-01096-zA comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatmentDanushiya Ehambarampillai0Murphy Lam Yim Wan1School of Medicine, Pharmacy and Biomedical Sciences, Faculty of Science and Health, University of PortsmouthDepartment of Laboratory Medicine, Division of Microbiology, Immunology and Glycobiology, Lund UniversityAbstract Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the pharmacological properties of Schisandra chinensis lignans, including their antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, antibacterial/viral, antidiabetic and anticancer effects. Their multifaceted mechanisms of action hold promise for therapeutic areas such as cancer, neurodegenerative diseases and metabolic disorders, aligning with urgent clinical needs. Additionally, this review explores the pharmacokinetics of these bioactive compounds, highlighting challenges in their absorption, distribution, metabolism and excretion, which impact their bioavailability. Recent advancements in drug delivery systems are discussed, highlighting their potential to enhance therapeutic efficacy in clinical settings. Furthermore, the synergistic effects of combining these lignans with other therapeutic agents are considered a strategy to increase their efficacy. Future research is imperative to identify additional active components and elucidate novel mechanisms of action, paving the way for expanded therapeutic applications and unlocking the full clinical potential of Schisandra chinensis in disease prevention and treatment.https://doi.org/10.1186/s13020-025-01096-zSchisandra chinensisLignansPharmacological propertiesPharmacokineticsMechanism of actionNovel therapeutics |
| spellingShingle | Danushiya Ehambarampillai Murphy Lam Yim Wan A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment Chinese Medicine Schisandra chinensis Lignans Pharmacological properties Pharmacokinetics Mechanism of action Novel therapeutics |
| title | A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment |
| title_full | A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment |
| title_fullStr | A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment |
| title_full_unstemmed | A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment |
| title_short | A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment |
| title_sort | comprehensive review of schisandra chinensis lignans pharmacokinetics pharmacological mechanisms and future prospects in disease prevention and treatment |
| topic | Schisandra chinensis Lignans Pharmacological properties Pharmacokinetics Mechanism of action Novel therapeutics |
| url | https://doi.org/10.1186/s13020-025-01096-z |
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