Associations of circulating adipokines and coronary artery disease in young adults
Aim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean a...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2024-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3965 |
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| author | A. D. Khudiakova Y. V. Polonskaya L. V. Shcherbakova V. S. Shramko N. A. Kuzminykh E. V. Kashtanova Yu. I. Ragino |
| author_facet | A. D. Khudiakova Y. V. Polonskaya L. V. Shcherbakova V. S. Shramko N. A. Kuzminykh E. V. Kashtanova Yu. I. Ragino |
| author_sort | A. D. Khudiakova |
| collection | DOAJ |
| description | Aim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean age was 36,7±6,0 years. Premature CAD was detected in 46 people, while 4 following subgroups were formed (138 people in total): with CAD and AO; with CAD, without AO; control groups by age and sex: without CAD, with AO; without CAD, without AO.Results. Premature CAD in young people is associated with an increase in non-high-density lipoprotein cholesterol (non-HDL-C). Univariate analysis found that the probability of CAD increased by 1% with an increase in adiponectin level, and by 0,2% with an increase of 1 ng/ml in resistin level. Multivariate regression analysis, including sex, age, waist circumference, non-HD-C, adiponectin, and resistin, significant associations were obtained for non-HDL-C and adiponectin. With AO, the CAD probability increased by 0,6% with an increase in plasminogen activator inhibitor-1 level (PAI-1). However, when non-HDL-C was included in the model, significance for this biomarker was not achieved.Conclusion. In young people, CAD is associated with increased levels of non-HDL cholesterol, adiponectin, resistin and PAI-1. Independent associations with premature CAD were obtained only for adiponectin, which makes this marker promising for study in young people. |
| format | Article |
| id | doaj-art-a1b32818fa38418daf902f0bf68d8ea4 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-a1b32818fa38418daf902f0bf68d8ea42025-08-20T03:18:37Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252024-06-0123510.15829/1728-8800-2024-39652987Associations of circulating adipokines and coronary artery disease in young adultsA. D. Khudiakova0Y. V. Polonskaya1L. V. Shcherbakova2V. S. Shramko3N. A. Kuzminykh4E. V. Kashtanova5Yu. I. Ragino6Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and GeneticsAim. To evaluate the associations of abdominal obesity (AO), adipokines and premature coronary artery disease (CAD) in young people for a deeper understanding of the pathogenesis of atherosclerotic diseases.Material and methods. A total of 1457 people were examined, including 653 (44,8%) men. Mean age was 36,7±6,0 years. Premature CAD was detected in 46 people, while 4 following subgroups were formed (138 people in total): with CAD and AO; with CAD, without AO; control groups by age and sex: without CAD, with AO; without CAD, without AO.Results. Premature CAD in young people is associated with an increase in non-high-density lipoprotein cholesterol (non-HDL-C). Univariate analysis found that the probability of CAD increased by 1% with an increase in adiponectin level, and by 0,2% with an increase of 1 ng/ml in resistin level. Multivariate regression analysis, including sex, age, waist circumference, non-HD-C, adiponectin, and resistin, significant associations were obtained for non-HDL-C and adiponectin. With AO, the CAD probability increased by 0,6% with an increase in plasminogen activator inhibitor-1 level (PAI-1). However, when non-HDL-C was included in the model, significance for this biomarker was not achieved.Conclusion. In young people, CAD is associated with increased levels of non-HDL cholesterol, adiponectin, resistin and PAI-1. Independent associations with premature CAD were obtained only for adiponectin, which makes this marker promising for study in young people.https://cardiovascular.elpub.ru/jour/article/view/3965premature coronary artery diseaseadiponectinresistinpai-1non-hdl cholesterolabdominal obesityyoung age |
| spellingShingle | A. D. Khudiakova Y. V. Polonskaya L. V. Shcherbakova V. S. Shramko N. A. Kuzminykh E. V. Kashtanova Yu. I. Ragino Associations of circulating adipokines and coronary artery disease in young adults Кардиоваскулярная терапия и профилактика premature coronary artery disease adiponectin resistin pai-1 non-hdl cholesterol abdominal obesity young age |
| title | Associations of circulating adipokines and coronary artery disease in young adults |
| title_full | Associations of circulating adipokines and coronary artery disease in young adults |
| title_fullStr | Associations of circulating adipokines and coronary artery disease in young adults |
| title_full_unstemmed | Associations of circulating adipokines and coronary artery disease in young adults |
| title_short | Associations of circulating adipokines and coronary artery disease in young adults |
| title_sort | associations of circulating adipokines and coronary artery disease in young adults |
| topic | premature coronary artery disease adiponectin resistin pai-1 non-hdl cholesterol abdominal obesity young age |
| url | https://cardiovascular.elpub.ru/jour/article/view/3965 |
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