Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process
The gas antisolvent (GAS) process has been employed for pharmaceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iranian Association of Chemical Engineering (IAChE)
2020-03-01
|
| Series: | Iranian Journal of Chemical Engineering |
| Subjects: | |
| Online Access: | https://www.ijche.com/article_119380_569cddf64832c5c2eb0e67737156079c.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850178351549906944 |
|---|---|
| author | M. Rahmanzadeh derisi N. Esfandiari |
| author_facet | M. Rahmanzadeh derisi N. Esfandiari |
| author_sort | M. Rahmanzadeh derisi |
| collection | DOAJ |
| description | The gas antisolvent (GAS) process has been employed for pharmaceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles in GAS process are not seen in any operating conditions. Thermodynamic modeling of GAS can evaluate the operating conditions. In this project, the effect of solvent on optimal thermodynamic conditions of the binary system (CO2, solvent) and ternary system (CO2, solvent, ampicillin) were investigated. The relative change in molar volume in different solvent (ethanol, 1-propanol, 1-butanol, and 1-pentanol) was studied for determination of the optimum operating conditions. The combination of Peng-Robinson EOS and Vidal and Michelsen mixing rule (LCVM) was selected to determine the optimum operating condition of the GAS process. The effect of solvent on minimum pressure was investigated. The calculated Pmin was 70, 70.86, 72.2 and 73.4 bar for ethanol, 1-propanol, 1-butanol, and 1-pantanol at, 308.15 K respectively. According to modeling results, when the molecular weight of the solvent was increased, the value of Pmin was increased. |
| format | Article |
| id | doaj-art-a1ab7d5ef0d54203ab4fe4f8698b8746 |
| institution | OA Journals |
| issn | 1735-5397 2008-2355 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Iranian Association of Chemical Engineering (IAChE) |
| record_format | Article |
| series | Iranian Journal of Chemical Engineering |
| spelling | doaj-art-a1ab7d5ef0d54203ab4fe4f8698b87462025-08-20T02:18:46ZengIranian Association of Chemical Engineering (IAChE)Iranian Journal of Chemical Engineering1735-53972008-23552020-03-01171374610.22034/ijche.2020.214680.1328119380Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS ProcessM. Rahmanzadeh derisi0N. Esfandiari1Department of Chemical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, IranThe gas antisolvent (GAS) process has been employed for pharmaceutical micronization. Ampicillin was dissolved in organic solvent and carbon dioxide as an antisolvent was injected into this solution, consequently, volume expansion and sharp reduction in liquid solvent power were shown. The particles in GAS process are not seen in any operating conditions. Thermodynamic modeling of GAS can evaluate the operating conditions. In this project, the effect of solvent on optimal thermodynamic conditions of the binary system (CO2, solvent) and ternary system (CO2, solvent, ampicillin) were investigated. The relative change in molar volume in different solvent (ethanol, 1-propanol, 1-butanol, and 1-pentanol) was studied for determination of the optimum operating conditions. The combination of Peng-Robinson EOS and Vidal and Michelsen mixing rule (LCVM) was selected to determine the optimum operating condition of the GAS process. The effect of solvent on minimum pressure was investigated. The calculated Pmin was 70, 70.86, 72.2 and 73.4 bar for ethanol, 1-propanol, 1-butanol, and 1-pantanol at, 308.15 K respectively. According to modeling results, when the molecular weight of the solvent was increased, the value of Pmin was increased.https://www.ijche.com/article_119380_569cddf64832c5c2eb0e67737156079c.pdfthermodynamic modelinggas processsolventampicillincarbon dioxide |
| spellingShingle | M. Rahmanzadeh derisi N. Esfandiari Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process Iranian Journal of Chemical Engineering thermodynamic modeling gas process solvent ampicillin carbon dioxide |
| title | Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process |
| title_full | Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process |
| title_fullStr | Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process |
| title_full_unstemmed | Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process |
| title_short | Effect of Solvent on the Optimal Thermodynamic Conditions of Ternary System (CO2, Alcohol, Ampicillin) in GAS Process |
| title_sort | effect of solvent on the optimal thermodynamic conditions of ternary system co2 alcohol ampicillin in gas process |
| topic | thermodynamic modeling gas process solvent ampicillin carbon dioxide |
| url | https://www.ijche.com/article_119380_569cddf64832c5c2eb0e67737156079c.pdf |
| work_keys_str_mv | AT mrahmanzadehderisi effectofsolventontheoptimalthermodynamicconditionsofternarysystemco2alcoholampicilliningasprocess AT nesfandiari effectofsolventontheoptimalthermodynamicconditionsofternarysystemco2alcoholampicilliningasprocess |