Gene Expression Profiling in Organ Transplantation
Aim of Review. Huge effort is being made among the transplant community investigating novel biomarkers that enable transplant clinicians to identify patients at risk for allograft rejection or those who will develop tolerance so that immunosuppression could be safely minimized or even ideally withd...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/180201 |
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| _version_ | 1849398508007718912 |
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| author | Osama Ashry Ahmed Gheith |
| author_facet | Osama Ashry Ahmed Gheith |
| author_sort | Osama Ashry Ahmed Gheith |
| collection | DOAJ |
| description | Aim of Review.
Huge effort is being made among the transplant community investigating novel
biomarkers that enable transplant clinicians to identify patients at risk for allograft
rejection or those who will develop tolerance so that immunosuppression could be
safely minimized or even ideally withdrawn.
Despite the important advances achieved in the identification of several potential
biomarkers of tolerance, rejection, or both, validation and demonstration of their clinical
utility still needs to be tested, which will need international cooperative networks.
It is important to note that the reproducibility of differently expressed genes might be
affected by many factors such as gene ranking and selection methods, inherent
differences between types, and the choice of thresholds. However, because microarray
analyses are expensive and time consuming and their statistical evaluation is often very
difficult, gene expression analysis using the RTPCR method is nowadays
recommended.
Conclusions.
In the field of organ transplantation, gene-expression-based decision might help in
improving patient and graft outcome and there are a multitude of studies showing that
gene-expression profiling is feasible. |
| format | Article |
| id | doaj-art-a19dc96d2f1f43e28595a3b2863d25ec |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-a19dc96d2f1f43e28595a3b2863d25ec2025-08-20T03:38:35ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/180201180201Gene Expression Profiling in Organ TransplantationOsama Ashry Ahmed Gheith0Urology and Nephrology Center, Mansoura University, Mansoura, EgyptAim of Review. Huge effort is being made among the transplant community investigating novel biomarkers that enable transplant clinicians to identify patients at risk for allograft rejection or those who will develop tolerance so that immunosuppression could be safely minimized or even ideally withdrawn. Despite the important advances achieved in the identification of several potential biomarkers of tolerance, rejection, or both, validation and demonstration of their clinical utility still needs to be tested, which will need international cooperative networks. It is important to note that the reproducibility of differently expressed genes might be affected by many factors such as gene ranking and selection methods, inherent differences between types, and the choice of thresholds. However, because microarray analyses are expensive and time consuming and their statistical evaluation is often very difficult, gene expression analysis using the RTPCR method is nowadays recommended. Conclusions. In the field of organ transplantation, gene-expression-based decision might help in improving patient and graft outcome and there are a multitude of studies showing that gene-expression profiling is feasible.http://dx.doi.org/10.4061/2011/180201 |
| spellingShingle | Osama Ashry Ahmed Gheith Gene Expression Profiling in Organ Transplantation International Journal of Nephrology |
| title | Gene Expression Profiling in Organ Transplantation |
| title_full | Gene Expression Profiling in Organ Transplantation |
| title_fullStr | Gene Expression Profiling in Organ Transplantation |
| title_full_unstemmed | Gene Expression Profiling in Organ Transplantation |
| title_short | Gene Expression Profiling in Organ Transplantation |
| title_sort | gene expression profiling in organ transplantation |
| url | http://dx.doi.org/10.4061/2011/180201 |
| work_keys_str_mv | AT osamaashryahmedgheith geneexpressionprofilinginorgantransplantation |