Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration

Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration

Abstract Non-viral DNA donor templates are commonly used for targeted genomic integration via homologous recombination (HR), with efficiency improved by CRISPR/Cas9 technology. Circular single-stranded DNA (cssDNA) has been used as a genome engineering catalyst (GATALYST) for efficient and safe gene...

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Bibliographic Details
Main Authors: Hangu Nam, Keqiang Xie, Ishita Majumdar, Jiao Wang, Shaobo Yang, Jakob Starzyk, Danna Lee, Richard Shan, Jiahe Li, Hao Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59790-3
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