Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study
Dead space fraction (Vd/Vt) measurement performed using volumetric capnography requires arterial blood gas (ABG) sampling to estimate the partial pressure of carbon dioxide (PaCO2). In recent years, transcutaneous capnography (PtcCO2) has emerged as a noninvasive method of estimating PaCO2. We hypot...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/9874150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849398366565302272 |
|---|---|
| author | Pradeep H. Lakshminarayana Adiba A. Geeti Umer M. Darr David A. Kaufman |
| author_facet | Pradeep H. Lakshminarayana Adiba A. Geeti Umer M. Darr David A. Kaufman |
| author_sort | Pradeep H. Lakshminarayana |
| collection | DOAJ |
| description | Dead space fraction (Vd/Vt) measurement performed using volumetric capnography requires arterial blood gas (ABG) sampling to estimate the partial pressure of carbon dioxide (PaCO2). In recent years, transcutaneous capnography (PtcCO2) has emerged as a noninvasive method of estimating PaCO2. We hypothesized that PtcCO2 can be used as a substitute for PaCO2 in the calculation of Vd/Vt. In this prospective pilot comparison study, 30 consecutive postcardiac surgery mechanically ventilated patients had Vd/Vt calculated separately using volumetric capnography by substituting PtcCO2 for PaCO2. The mean Vd/Vt calculated using PaCO2 and PtcCO2 was 0.48 ± 0.09 and 0.53 ± 0.08, respectively, with a strong positive correlation between the two methods of calculation (Pearson’s correlation = 0.87, p<0.05). Bland-Altman analysis showed a mean difference of −0.05 (95% CI: −0.01 to −0.09) between the two methods. PtcCO2 measurements can provide a noninvasive means to measure Vd/Vt, thus accessing important physiologic information and prognostic assessment in patients receiving mechanical ventilation. |
| format | Article |
| id | doaj-art-a18c8e6f7e7247c7b3803c7fe4ef72c6 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-a18c8e6f7e7247c7b3803c7fe4ef72c62025-08-20T03:38:38ZengWileyCritical Care Research and Practice2090-13052090-13132016-01-01201610.1155/2016/98741509874150Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot StudyPradeep H. Lakshminarayana0Adiba A. Geeti1Umer M. Darr2David A. Kaufman3Section of Pulmonary, Critical Care and Sleep Medicine, Bridgeport Hospital, Yale New Haven Health, 267 Grant Street, Bridgeport, CT 06610, USASection of Pulmonary, Critical Care and Sleep Medicine, Bridgeport Hospital, Yale New Haven Health, 267 Grant Street, Bridgeport, CT 06610, USAYale Cardiac Surgery, Bridgeport Hospital, 267 Grant Street, Bridgeport, CT 06610, USASection of Pulmonary, Critical Care and Sleep Medicine, Bridgeport Hospital, Yale New Haven Health, 267 Grant Street, Bridgeport, CT 06610, USADead space fraction (Vd/Vt) measurement performed using volumetric capnography requires arterial blood gas (ABG) sampling to estimate the partial pressure of carbon dioxide (PaCO2). In recent years, transcutaneous capnography (PtcCO2) has emerged as a noninvasive method of estimating PaCO2. We hypothesized that PtcCO2 can be used as a substitute for PaCO2 in the calculation of Vd/Vt. In this prospective pilot comparison study, 30 consecutive postcardiac surgery mechanically ventilated patients had Vd/Vt calculated separately using volumetric capnography by substituting PtcCO2 for PaCO2. The mean Vd/Vt calculated using PaCO2 and PtcCO2 was 0.48 ± 0.09 and 0.53 ± 0.08, respectively, with a strong positive correlation between the two methods of calculation (Pearson’s correlation = 0.87, p<0.05). Bland-Altman analysis showed a mean difference of −0.05 (95% CI: −0.01 to −0.09) between the two methods. PtcCO2 measurements can provide a noninvasive means to measure Vd/Vt, thus accessing important physiologic information and prognostic assessment in patients receiving mechanical ventilation.http://dx.doi.org/10.1155/2016/9874150 |
| spellingShingle | Pradeep H. Lakshminarayana Adiba A. Geeti Umer M. Darr David A. Kaufman Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study Critical Care Research and Practice |
| title | Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study |
| title_full | Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study |
| title_fullStr | Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study |
| title_full_unstemmed | Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study |
| title_short | Can Transcutaneous CO2 Tension Be Used to Calculate Ventilatory Dead Space? A Pilot Study |
| title_sort | can transcutaneous co2 tension be used to calculate ventilatory dead space a pilot study |
| url | http://dx.doi.org/10.1155/2016/9874150 |
| work_keys_str_mv | AT pradeephlakshminarayana cantranscutaneousco2tensionbeusedtocalculateventilatorydeadspaceapilotstudy AT adibaageeti cantranscutaneousco2tensionbeusedtocalculateventilatorydeadspaceapilotstudy AT umermdarr cantranscutaneousco2tensionbeusedtocalculateventilatorydeadspaceapilotstudy AT davidakaufman cantranscutaneousco2tensionbeusedtocalculateventilatorydeadspaceapilotstudy |