Cancer Cachexia and MicroRNAs
Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the p...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/367561 |
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| author | Rodolfo Gonzalez Camargo Henrique Quintas Teixeira Ribeiro Murilo Vieira Geraldo Emídio Matos-Neto Rodrigo Xavier Neves Luiz Carlos Carnevali Felipe Fedrizzi Donatto Paulo S. M. Alcântara José P. Ottoch Marília Seelaender |
| author_facet | Rodolfo Gonzalez Camargo Henrique Quintas Teixeira Ribeiro Murilo Vieira Geraldo Emídio Matos-Neto Rodrigo Xavier Neves Luiz Carlos Carnevali Felipe Fedrizzi Donatto Paulo S. M. Alcântara José P. Ottoch Marília Seelaender |
| author_sort | Rodolfo Gonzalez Camargo |
| collection | DOAJ |
| description | Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment. |
| format | Article |
| id | doaj-art-a18b6496ea2b4693be6ee0bfe969ef05 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a18b6496ea2b4693be6ee0bfe969ef052025-08-20T02:20:41ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/367561367561Cancer Cachexia and MicroRNAsRodolfo Gonzalez Camargo0Henrique Quintas Teixeira Ribeiro1Murilo Vieira Geraldo2Emídio Matos-Neto3Rodrigo Xavier Neves4Luiz Carlos Carnevali5Felipe Fedrizzi Donatto6Paulo S. M. Alcântara7José P. Ottoch8Marília Seelaender9Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilNAPmiR—miRNA Research Group, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilDepartment of Clinical Surgery, University of São Paulo, Avenida Professor Lineu Prestes 2565, Cidade Universitária, 05508-000 São Paulo, SP, BrazilDepartment of Clinical Surgery, University of São Paulo, Avenida Professor Lineu Prestes 2565, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 1524, Cidade Universitária, 05508-000 São Paulo, SP, BrazilCancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment.http://dx.doi.org/10.1155/2015/367561 |
| spellingShingle | Rodolfo Gonzalez Camargo Henrique Quintas Teixeira Ribeiro Murilo Vieira Geraldo Emídio Matos-Neto Rodrigo Xavier Neves Luiz Carlos Carnevali Felipe Fedrizzi Donatto Paulo S. M. Alcântara José P. Ottoch Marília Seelaender Cancer Cachexia and MicroRNAs Mediators of Inflammation |
| title | Cancer Cachexia and MicroRNAs |
| title_full | Cancer Cachexia and MicroRNAs |
| title_fullStr | Cancer Cachexia and MicroRNAs |
| title_full_unstemmed | Cancer Cachexia and MicroRNAs |
| title_short | Cancer Cachexia and MicroRNAs |
| title_sort | cancer cachexia and micrornas |
| url | http://dx.doi.org/10.1155/2015/367561 |
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