PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE
In experiments on rats (290 animals ) exposed to chronic γ-radiation in the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class-glutapyrone-together with drinking water during 6 months reduced the rate of malignant neoplasms from 26,5% in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev
2015-09-01
|
| Series: | Радиационная гигиена |
| Subjects: | |
| Online Access: | https://www.radhyg.ru/jour/article/view/130 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849243241897000960 |
|---|---|
| author | L. P. Vartanyan E. V. Ivanov A. B. Marcochev E. A. Bisenieks S. F. Vershinina G. F. Gornaeva Yu. I. Pustovalov T. V. Ponomareva |
| author_facet | L. P. Vartanyan E. V. Ivanov A. B. Marcochev E. A. Bisenieks S. F. Vershinina G. F. Gornaeva Yu. I. Pustovalov T. V. Ponomareva |
| author_sort | L. P. Vartanyan |
| collection | DOAJ |
| description | In experiments on rats (290 animals ) exposed to chronic γ-radiation in the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class-glutapyrone-together with drinking water during 6 months reduced the rate of malignant neoplasms from 26,5% in the control group to 13% in the treated animals. In radiation-exposed rats that received glutapyrone there was a narrowing of spectrum of the emerged neoplasms (connectively-tissual tumors only) as compared to the animals of the radiated control group, where blastomas of epithelium and lymphoid origin were also revealed. Low toxicity of glutapyrone and its anticarcinogenic action show the possibility of practical application of preparation for prevention radiation carcinogenesis. |
| format | Article |
| id | doaj-art-a1882dce5eff4eb4a9dec77c0ab8a191 |
| institution | Kabale University |
| issn | 1998-426X |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev |
| record_format | Article |
| series | Радиационная гигиена |
| spelling | doaj-art-a1882dce5eff4eb4a9dec77c0ab8a1912025-08-20T03:59:31ZengSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. RamzaevРадиационная гигиена1998-426X2015-09-015258129PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONEL. P. Vartanyan0E. V. Ivanov1A. B. Marcochev2E. A. Bisenieks3S. F. Vershinina4G. F. Gornaeva5Yu. I. Pustovalov6T. V. Ponomareva7Russian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgRussian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgRussian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgLatvian Institute of Organic Synthesis, RigaRussian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgRussian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgRussian Research Centre for Radiology and Surgical Technologies, Saint-PetersburgFederal Scientific Organization «Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev», Saint-PetersburgIn experiments on rats (290 animals ) exposed to chronic γ-radiation in the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class-glutapyrone-together with drinking water during 6 months reduced the rate of malignant neoplasms from 26,5% in the control group to 13% in the treated animals. In radiation-exposed rats that received glutapyrone there was a narrowing of spectrum of the emerged neoplasms (connectively-tissual tumors only) as compared to the animals of the radiated control group, where blastomas of epithelium and lymphoid origin were also revealed. Low toxicity of glutapyrone and its anticarcinogenic action show the possibility of practical application of preparation for prevention radiation carcinogenesis.https://www.radhyg.ru/jour/article/view/130chronic γ-ray exposure of the ratsanticarcinogenic actionglutapyrone |
| spellingShingle | L. P. Vartanyan E. V. Ivanov A. B. Marcochev E. A. Bisenieks S. F. Vershinina G. F. Gornaeva Yu. I. Pustovalov T. V. Ponomareva PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE Радиационная гигиена chronic γ-ray exposure of the rats anticarcinogenic action glutapyrone |
| title | PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE |
| title_full | PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE |
| title_fullStr | PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE |
| title_full_unstemmed | PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE |
| title_short | PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE |
| title_sort | prevention of radiation carcinogenesis in rats by means of oxypyridine derivative glutapyrone |
| topic | chronic γ-ray exposure of the rats anticarcinogenic action glutapyrone |
| url | https://www.radhyg.ru/jour/article/view/130 |
| work_keys_str_mv | AT lpvartanyan preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT evivanov preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT abmarcochev preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT eabisenieks preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT sfvershinina preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT gfgornaeva preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT yuipustovalov preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone AT tvponomareva preventionofradiationcarcinogenesisinratsbymeansofoxypyridinederivativeglutapyrone |