Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation
The aim of this study is to identify factors influencing the likelihood of the thrombus dissolution in the left atrial appendage in patients with persistent nonvalvular atrial fibrillation. Material and methods. A repeated transesophageal echocardiography was performed in 88 patients with persistent...
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SINAPS LLC
2022-03-01
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| Series: | Архивъ внутренней медицины |
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| author | E. S. Mazur V. V. Mazur N. D. Bazhenov Yu. A. Orlov |
| author_facet | E. S. Mazur V. V. Mazur N. D. Bazhenov Yu. A. Orlov |
| author_sort | E. S. Mazur |
| collection | DOAJ |
| description | The aim of this study is to identify factors influencing the likelihood of the thrombus dissolution in the left atrial appendage in patients with persistent nonvalvular atrial fibrillation. Material and methods. A repeated transesophageal echocardiography was performed in 88 patients with persistent nonvalvular atrial fibrillation and with the left atrial appendage thrombus at the first transesophageal echocardiography. Results. The second transesophageal echocardiography was performed on average 30.0 (22.0; 40.0) days after the first one, the thrombus dissolution in the left atrial appendage was revealed in 60 (68.2%) patients. The multivariate logistic regression analysis showed that the chances of the thrombus dissolution increased by 5.789 (1.907–17.568) times with the thrombus size not more 25 mm, by 5.318 (1.325–21.353) times with the left atrial appendage emptying flow velocity not less 20 cm/s and 3.687 (1.229–11.059) times when prescribing the direct oral anticoagulants, and not warfarin. Combination of two or more factors give the probability of the thrombus dissolution of more than 89.6%. Conclusion. The probability of the thrombus dissolution in left atrial appendage in patients with persistent nonvalvular atrial fibrillation increases with a small thrombus size, a high the left atrial appendage emptying flow velocity, and if direct oral anticoagulants were prescribed. |
| format | Article |
| id | doaj-art-a18562cbc7cb4e1a957ec6a7e73347c9 |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-a18562cbc7cb4e1a957ec6a7e73347c92025-08-20T03:37:56ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642022-03-0112212913510.20514/2226-6704-2021-12-2-129-135886Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial FibrillationE. S. Mazur0V. V. Mazur1N. D. Bazhenov2Yu. A. Orlov3Tver State Medical UniversityTver State Medical UniversityTver State Medical UniversityTver State Medical UniversityThe aim of this study is to identify factors influencing the likelihood of the thrombus dissolution in the left atrial appendage in patients with persistent nonvalvular atrial fibrillation. Material and methods. A repeated transesophageal echocardiography was performed in 88 patients with persistent nonvalvular atrial fibrillation and with the left atrial appendage thrombus at the first transesophageal echocardiography. Results. The second transesophageal echocardiography was performed on average 30.0 (22.0; 40.0) days after the first one, the thrombus dissolution in the left atrial appendage was revealed in 60 (68.2%) patients. The multivariate logistic regression analysis showed that the chances of the thrombus dissolution increased by 5.789 (1.907–17.568) times with the thrombus size not more 25 mm, by 5.318 (1.325–21.353) times with the left atrial appendage emptying flow velocity not less 20 cm/s and 3.687 (1.229–11.059) times when prescribing the direct oral anticoagulants, and not warfarin. Combination of two or more factors give the probability of the thrombus dissolution of more than 89.6%. Conclusion. The probability of the thrombus dissolution in left atrial appendage in patients with persistent nonvalvular atrial fibrillation increases with a small thrombus size, a high the left atrial appendage emptying flow velocity, and if direct oral anticoagulants were prescribed.https://www.medarhive.ru/jour/article/view/1406persistent atrial fibrillationtransesophageal echocardiographyleft atrial appendage thrombosisoral anticoagulants |
| spellingShingle | E. S. Mazur V. V. Mazur N. D. Bazhenov Yu. A. Orlov Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation Архивъ внутренней медицины persistent atrial fibrillation transesophageal echocardiography left atrial appendage thrombosis oral anticoagulants |
| title | Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation |
| title_full | Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation |
| title_fullStr | Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation |
| title_full_unstemmed | Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation |
| title_short | Predictors of Thrombus Dissolution in the Left Atrial Appendage in Patients with Persistent Nonvalvular Atrial Fibrillation |
| title_sort | predictors of thrombus dissolution in the left atrial appendage in patients with persistent nonvalvular atrial fibrillation |
| topic | persistent atrial fibrillation transesophageal echocardiography left atrial appendage thrombosis oral anticoagulants |
| url | https://www.medarhive.ru/jour/article/view/1406 |
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