Double trouble: how c-MET and HER2 fuel bladder cancer progression
Abstract Background Bladder cancer is still a prevalent, heterogeneous, and challenging disease. Most cases are non-muscle invasive and carry a significant risk of recurrence and progression despite current advances in therapeutic options. Main c-MET and HER2 belong to the receptor tyrosine kinase f...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-12-01
|
| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-024-00618-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850134382024589312 |
|---|---|
| author | E. M. Naguib E. F. Ismail D. I. Badran M. H. Sherief T. B. El-Abaseri |
| author_facet | E. M. Naguib E. F. Ismail D. I. Badran M. H. Sherief T. B. El-Abaseri |
| author_sort | E. M. Naguib |
| collection | DOAJ |
| description | Abstract Background Bladder cancer is still a prevalent, heterogeneous, and challenging disease. Most cases are non-muscle invasive and carry a significant risk of recurrence and progression despite current advances in therapeutic options. Main c-MET and HER2 belong to the receptor tyrosine kinase family, which has been intensively studied in cancer. Both receptors are upregulated in bladder cancer and have been connected to tumor development and progression by activating a variety of signaling pathways that control proliferation, migration, and metastasis. C-MET and HER2 are indicators of aggressive bladder cancer and possible therapeutic targets. This review will investigate the contributions of c-MET and HER2 in the genesis and progression of bladder cancer, the implications for therapy and ongoing research in this field. Conclusion Targeting c-MET and HER2 together, either as monotherapy or combined therapy, might become promising in managing aggressive bladder cancer. |
| format | Article |
| id | doaj-art-a182dbd59af84e6483e8be499ece46c8 |
| institution | OA Journals |
| issn | 2090-2441 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-a182dbd59af84e6483e8be499ece46c82025-08-20T02:31:44ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412024-12-012511810.1186/s43042-024-00618-yDouble trouble: how c-MET and HER2 fuel bladder cancer progressionE. M. Naguib0E. F. Ismail1D. I. Badran2M. H. Sherief3T. B. El-Abaseri4Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityUrology Department, Faculty of Medicine, Suez Canal UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityAbstract Background Bladder cancer is still a prevalent, heterogeneous, and challenging disease. Most cases are non-muscle invasive and carry a significant risk of recurrence and progression despite current advances in therapeutic options. Main c-MET and HER2 belong to the receptor tyrosine kinase family, which has been intensively studied in cancer. Both receptors are upregulated in bladder cancer and have been connected to tumor development and progression by activating a variety of signaling pathways that control proliferation, migration, and metastasis. C-MET and HER2 are indicators of aggressive bladder cancer and possible therapeutic targets. This review will investigate the contributions of c-MET and HER2 in the genesis and progression of bladder cancer, the implications for therapy and ongoing research in this field. Conclusion Targeting c-MET and HER2 together, either as monotherapy or combined therapy, might become promising in managing aggressive bladder cancer.https://doi.org/10.1186/s43042-024-00618-yBladder cancerHER2c-METRecurrence |
| spellingShingle | E. M. Naguib E. F. Ismail D. I. Badran M. H. Sherief T. B. El-Abaseri Double trouble: how c-MET and HER2 fuel bladder cancer progression Egyptian Journal of Medical Human Genetics Bladder cancer HER2 c-MET Recurrence |
| title | Double trouble: how c-MET and HER2 fuel bladder cancer progression |
| title_full | Double trouble: how c-MET and HER2 fuel bladder cancer progression |
| title_fullStr | Double trouble: how c-MET and HER2 fuel bladder cancer progression |
| title_full_unstemmed | Double trouble: how c-MET and HER2 fuel bladder cancer progression |
| title_short | Double trouble: how c-MET and HER2 fuel bladder cancer progression |
| title_sort | double trouble how c met and her2 fuel bladder cancer progression |
| topic | Bladder cancer HER2 c-MET Recurrence |
| url | https://doi.org/10.1186/s43042-024-00618-y |
| work_keys_str_mv | AT emnaguib doubletroublehowcmetandher2fuelbladdercancerprogression AT efismail doubletroublehowcmetandher2fuelbladdercancerprogression AT dibadran doubletroublehowcmetandher2fuelbladdercancerprogression AT mhsherief doubletroublehowcmetandher2fuelbladdercancerprogression AT tbelabaseri doubletroublehowcmetandher2fuelbladdercancerprogression |