Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility
Obesity increases the risk of anovulation, insulin resistance, hyperandrogenism, and endometrial dysfunction, resulting in women with infertility and increasing preconceptional and pregnancy complications. Bariatric surgery has been described as the most effective intervention for obesity, with impr...
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MDPI AG
2025-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/15/4/260 |
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| author | Paulo César Gete Palacios Alberto Moscona-Nissan Renata Saucedo Aldo Ferreira-Hermosillo |
| author_facet | Paulo César Gete Palacios Alberto Moscona-Nissan Renata Saucedo Aldo Ferreira-Hermosillo |
| author_sort | Paulo César Gete Palacios |
| collection | DOAJ |
| description | Obesity increases the risk of anovulation, insulin resistance, hyperandrogenism, and endometrial dysfunction, resulting in women with infertility and increasing preconceptional and pregnancy complications. Bariatric surgery has been described as the most effective intervention for obesity, with improved fertility outcomes. However, its invasive nature increases the potential of nutritional deficiencies and the need for a delayed conception post-surgery. On the other hand, pharmacological treatments such as glucagon-like-peptide 1 receptor agonists offer non-invasive alternatives with promising results in body weight, improving insulin sensitivity and restoring ovarian function. However, their use must be discontinued before conception due to potential fetal risks. Other available pharmacological treatment options encompass topiramate, phentermine, and Orlistat. The choice of treatment must be individualized considering cost-effectiveness, accessibility, obesity severity, reproductive goals, and associated risks within each patient. A multidisciplinary approach is essential to optimize metabolic and reproductive health in obesity and infertility. This review will examine the impact on metabolism when comparing surgical and pharmacological interventions for weight loss in women with infertility. |
| format | Article |
| id | doaj-art-a1751694ca3a4dee89fbba5cc1a84cea |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-a1751694ca3a4dee89fbba5cc1a84cea2025-08-20T02:28:24ZengMDPI AGMetabolites2218-19892025-04-0115426010.3390/metabo15040260Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with InfertilityPaulo César Gete Palacios0Alberto Moscona-Nissan1Renata Saucedo2Aldo Ferreira-Hermosillo3 Unidad de Investigación Médica en Enfermedades Endocrinas, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, México City 06720, Mexico Unidad de Investigación Médica en Enfermedades Endocrinas, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, México City 06720, Mexico Unidad de Investigación Médica en Enfermedades Endocrinas, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, México City 06720, Mexico Unidad de Investigación Médica en Enfermedades Endocrinas, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, México City 06720, MexicoObesity increases the risk of anovulation, insulin resistance, hyperandrogenism, and endometrial dysfunction, resulting in women with infertility and increasing preconceptional and pregnancy complications. Bariatric surgery has been described as the most effective intervention for obesity, with improved fertility outcomes. However, its invasive nature increases the potential of nutritional deficiencies and the need for a delayed conception post-surgery. On the other hand, pharmacological treatments such as glucagon-like-peptide 1 receptor agonists offer non-invasive alternatives with promising results in body weight, improving insulin sensitivity and restoring ovarian function. However, their use must be discontinued before conception due to potential fetal risks. Other available pharmacological treatment options encompass topiramate, phentermine, and Orlistat. The choice of treatment must be individualized considering cost-effectiveness, accessibility, obesity severity, reproductive goals, and associated risks within each patient. A multidisciplinary approach is essential to optimize metabolic and reproductive health in obesity and infertility. This review will examine the impact on metabolism when comparing surgical and pharmacological interventions for weight loss in women with infertility.https://www.mdpi.com/2218-1989/15/4/260obesityfemale fertilitypregnancyfemale sexual function |
| spellingShingle | Paulo César Gete Palacios Alberto Moscona-Nissan Renata Saucedo Aldo Ferreira-Hermosillo Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility Metabolites obesity female fertility pregnancy female sexual function |
| title | Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility |
| title_full | Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility |
| title_fullStr | Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility |
| title_full_unstemmed | Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility |
| title_short | Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility |
| title_sort | impact on metabolism generated by surgical and pharmacological interventions for weight loss in women with infertility |
| topic | obesity female fertility pregnancy female sexual function |
| url | https://www.mdpi.com/2218-1989/15/4/260 |
| work_keys_str_mv | AT paulocesargetepalacios impactonmetabolismgeneratedbysurgicalandpharmacologicalinterventionsforweightlossinwomenwithinfertility AT albertomosconanissan impactonmetabolismgeneratedbysurgicalandpharmacologicalinterventionsforweightlossinwomenwithinfertility AT renatasaucedo impactonmetabolismgeneratedbysurgicalandpharmacologicalinterventionsforweightlossinwomenwithinfertility AT aldoferreirahermosillo impactonmetabolismgeneratedbysurgicalandpharmacologicalinterventionsforweightlossinwomenwithinfertility |