Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy
Reflectance spectroscopy is a low-cost, nondestructive, and noninvasive method for detection of neoplastic lesions of mucosal tissue. This study aims to evaluate the capability of reflectance spectroscopy system under white light (400–700 nm) with a multivariate statistical analysis for distinguishi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2016/1596845 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169635549216768 |
|---|---|
| author | Zhihong Xu Wei Huang Duo Lin Shanshan Wu Maowen Chen Xiaosong Ge Xueliang Lin Liqing Sun |
| author_facet | Zhihong Xu Wei Huang Duo Lin Shanshan Wu Maowen Chen Xiaosong Ge Xueliang Lin Liqing Sun |
| author_sort | Zhihong Xu |
| collection | DOAJ |
| description | Reflectance spectroscopy is a low-cost, nondestructive, and noninvasive method for detection of neoplastic lesions of mucosal tissue. This study aims to evaluate the capability of reflectance spectroscopy system under white light (400–700 nm) with a multivariate statistical analysis for distinguishing nasopharyngeal carcinoma (NPC) from nasopharyngeal benign ex vivo tissues. High quality reflectance spectra were acquired from nasopharyngeal ex vivo tissues belonging to 18 noncancerous and 19 cancerous subjects, and the combination of principal component analysis-linear discriminant analysis (PCA-LDA) along with leave-one-spectrum-out cross-validation (LOOCV) diagnostic algorithm was subsequently employed to classify different types of tissue group, achieving a diagnostic sensitivity of 73.7% and a specificity of 72.2%. Furthermore, in order to distinguish NPC from nasopharyngeal benign ex vivo tissues based on reflectance spectra simply, spectral intensity ratios of oxyhemoglobin (R540/R576) were used as an indicator of the carcinogenesis associated transformation in the hemoglobin oxygenation. This tentative work demonstrated the potential of reflectance spectroscopy for NPC detection using ex vivo tissue and has significant experimental and clinical value for further in vivo NPC detection in the future. |
| format | Article |
| id | doaj-art-a172fe8e46234cde86e91a2c3c30de55 |
| institution | OA Journals |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-a172fe8e46234cde86e91a2c3c30de552025-08-20T02:20:41ZengWileyJournal of Spectroscopy2314-49202314-49392016-01-01201610.1155/2016/15968451596845Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance SpectroscopyZhihong Xu0Wei Huang1Duo Lin2Shanshan Wu3Maowen Chen4Xiaosong Ge5Xueliang Lin6Liqing Sun7Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaKey Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, ChinaAffiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou 350009, ChinaReflectance spectroscopy is a low-cost, nondestructive, and noninvasive method for detection of neoplastic lesions of mucosal tissue. This study aims to evaluate the capability of reflectance spectroscopy system under white light (400–700 nm) with a multivariate statistical analysis for distinguishing nasopharyngeal carcinoma (NPC) from nasopharyngeal benign ex vivo tissues. High quality reflectance spectra were acquired from nasopharyngeal ex vivo tissues belonging to 18 noncancerous and 19 cancerous subjects, and the combination of principal component analysis-linear discriminant analysis (PCA-LDA) along with leave-one-spectrum-out cross-validation (LOOCV) diagnostic algorithm was subsequently employed to classify different types of tissue group, achieving a diagnostic sensitivity of 73.7% and a specificity of 72.2%. Furthermore, in order to distinguish NPC from nasopharyngeal benign ex vivo tissues based on reflectance spectra simply, spectral intensity ratios of oxyhemoglobin (R540/R576) were used as an indicator of the carcinogenesis associated transformation in the hemoglobin oxygenation. This tentative work demonstrated the potential of reflectance spectroscopy for NPC detection using ex vivo tissue and has significant experimental and clinical value for further in vivo NPC detection in the future.http://dx.doi.org/10.1155/2016/1596845 |
| spellingShingle | Zhihong Xu Wei Huang Duo Lin Shanshan Wu Maowen Chen Xiaosong Ge Xueliang Lin Liqing Sun Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy Journal of Spectroscopy |
| title | Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy |
| title_full | Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy |
| title_fullStr | Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy |
| title_full_unstemmed | Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy |
| title_short | Discrimination of Nasopharyngeal Carcinoma from Noncancerous Ex Vivo Tissue Using Reflectance Spectroscopy |
| title_sort | discrimination of nasopharyngeal carcinoma from noncancerous ex vivo tissue using reflectance spectroscopy |
| url | http://dx.doi.org/10.1155/2016/1596845 |
| work_keys_str_mv | AT zhihongxu discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT weihuang discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT duolin discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT shanshanwu discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT maowenchen discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT xiaosongge discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT xuelianglin discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy AT liqingsun discriminationofnasopharyngealcarcinomafromnoncancerousexvivotissueusingreflectancespectroscopy |