Valence and salience encoding in the central amygdala
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) and positive (reward) affective behaviors. The CeA has been proposed to encode affective information in the form of valence (whether the stimulus is good or bad) or salience (how signi...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2025-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/101980 |
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| author | Mi-Seon Kong Ethan Ancell Daniela M Witten Larry S Zweifel |
| author_facet | Mi-Seon Kong Ethan Ancell Daniela M Witten Larry S Zweifel |
| author_sort | Mi-Seon Kong |
| collection | DOAJ |
| description | The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) and positive (reward) affective behaviors. The CeA has been proposed to encode affective information in the form of valence (whether the stimulus is good or bad) or salience (how significant is the stimulus), but the extent to which these two types of stimulus representation occur in the CeA is not known. Here, we used single cell calcium imaging in mice during appetitive and aversive conditioning and found that majority of CeA neurons (~65%) encode the valence of the unconditioned stimulus (US) with a smaller subset of cells (~15%) encoding the salience of the US. Valence and salience encoding of the conditioned stimulus (CS) was also observed, albeit to a lesser extent. These findings show that the CeA is a site of convergence for encoding oppositely valenced US information. |
| format | Article |
| id | doaj-art-a165bad0ed79451fb33c2712b77c5b48 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-a165bad0ed79451fb33c2712b77c5b482025-01-10T15:33:45ZengeLife Sciences Publications LtdeLife2050-084X2025-01-011310.7554/eLife.101980Valence and salience encoding in the central amygdalaMi-Seon Kong0https://orcid.org/0000-0001-8970-7034Ethan Ancell1Daniela M Witten2Larry S Zweifel3https://orcid.org/0000-0003-3465-5331Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United StatesDepartment of Statistics, University of Washington, Seattle, United StatesDepartment of Statistics, University of Washington, Seattle, United States; Department of Biostatistics, University of Washington, Seattle, United StatesDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States; Department of Pharmacology, University of Washington, Seattle, United StatesThe central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) and positive (reward) affective behaviors. The CeA has been proposed to encode affective information in the form of valence (whether the stimulus is good or bad) or salience (how significant is the stimulus), but the extent to which these two types of stimulus representation occur in the CeA is not known. Here, we used single cell calcium imaging in mice during appetitive and aversive conditioning and found that majority of CeA neurons (~65%) encode the valence of the unconditioned stimulus (US) with a smaller subset of cells (~15%) encoding the salience of the US. Valence and salience encoding of the conditioned stimulus (CS) was also observed, albeit to a lesser extent. These findings show that the CeA is a site of convergence for encoding oppositely valenced US information.https://elifesciences.org/articles/101980central amygdalasaliencevalencerewardfear |
| spellingShingle | Mi-Seon Kong Ethan Ancell Daniela M Witten Larry S Zweifel Valence and salience encoding in the central amygdala eLife central amygdala salience valence reward fear |
| title | Valence and salience encoding in the central amygdala |
| title_full | Valence and salience encoding in the central amygdala |
| title_fullStr | Valence and salience encoding in the central amygdala |
| title_full_unstemmed | Valence and salience encoding in the central amygdala |
| title_short | Valence and salience encoding in the central amygdala |
| title_sort | valence and salience encoding in the central amygdala |
| topic | central amygdala salience valence reward fear |
| url | https://elifesciences.org/articles/101980 |
| work_keys_str_mv | AT miseonkong valenceandsalienceencodinginthecentralamygdala AT ethanancell valenceandsalienceencodinginthecentralamygdala AT danielamwitten valenceandsalienceencodinginthecentralamygdala AT larryszweifel valenceandsalienceencodinginthecentralamygdala |