Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients
Abstract Purpose This study aimed to investigate the clinical significance of E-cadherin expression levels in colorectal cancer tissues and explore the relationship between E-cadherin expression and tumor node metastasis (TNM) stage. The goal was to establish a more accurate prognostic prediction fo...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13539-9 |
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| author | Jae-Ghi Lee Ilkyu Park Hannah Lee Seungyoon Nam Jisup Kim Won-Suk Lee Myunghee Kang Jung Ho Kim |
| author_facet | Jae-Ghi Lee Ilkyu Park Hannah Lee Seungyoon Nam Jisup Kim Won-Suk Lee Myunghee Kang Jung Ho Kim |
| author_sort | Jae-Ghi Lee |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to investigate the clinical significance of E-cadherin expression levels in colorectal cancer tissues and explore the relationship between E-cadherin expression and tumor node metastasis (TNM) stage. The goal was to establish a more accurate prognostic prediction for colorectal cancer patients by analyzing E-cadherin expression levels alongside TNM staging. Methods The study examined colorectal cancer patients by dividing them into groups based on E-cadherin expression levels. It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). Additionally, the prognosis of patients was analyzed by combining E-cadherin expression levels with TNM staging, particularly focusing on patients in stages III and IV. Results The E-cadherinLow group had significantly worse outcomes, with HRs of 2.30 for EFS and 2.76 for DSS compared to the E-cadherinHigh group. When combined with TNM stage III/IV, patients with E-cadherinLow expression showed a poor prognosis, with HRs of 1.93 for EFS and 2.35 for DSS compared to those with E-cadherinHigh expression at the same TNM stage. Conclusions Low levels of E-cadherin expression are associated with a poor prognosis and decreased survival in colorectal cancer patients. Combining E-cadherin expression levels with TNM staging provides a more precise prediction of patient prognosis and survival, potentially guiding personalized treatment strategies. |
| format | Article |
| id | doaj-art-a165b4faa5a04e309093dc9a95a315af |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-a165b4faa5a04e309093dc9a95a315af2025-02-09T12:41:32ZengBMCBMC Cancer1471-24072025-01-0125111010.1186/s12885-025-13539-9Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patientsJae-Ghi Lee0Ilkyu Park1Hannah Lee2Seungyoon Nam3Jisup Kim4Won-Suk Lee5Myunghee Kang6Jung Ho Kim7Gachon Medical Research Institute, Gachon Biomedical Convergence Institute, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityGachon Medical Research Institute, Gachon Biomedical Convergence Institute, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityDepartment of Internal Medicine, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityAI Convergence Center for Medical Science, Department of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of MedicineDepartment of Pathology, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityDepartment of Surgery, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityDepartment of Pathology, Dongkang Medical CenterGachon Medical Research Institute, Gachon Biomedical Convergence Institute, College of Medicine, Gachon University Gil Medical Center, Gachon UniversityAbstract Purpose This study aimed to investigate the clinical significance of E-cadherin expression levels in colorectal cancer tissues and explore the relationship between E-cadherin expression and tumor node metastasis (TNM) stage. The goal was to establish a more accurate prognostic prediction for colorectal cancer patients by analyzing E-cadherin expression levels alongside TNM staging. Methods The study examined colorectal cancer patients by dividing them into groups based on E-cadherin expression levels. It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). Additionally, the prognosis of patients was analyzed by combining E-cadherin expression levels with TNM staging, particularly focusing on patients in stages III and IV. Results The E-cadherinLow group had significantly worse outcomes, with HRs of 2.30 for EFS and 2.76 for DSS compared to the E-cadherinHigh group. When combined with TNM stage III/IV, patients with E-cadherinLow expression showed a poor prognosis, with HRs of 1.93 for EFS and 2.35 for DSS compared to those with E-cadherinHigh expression at the same TNM stage. Conclusions Low levels of E-cadherin expression are associated with a poor prognosis and decreased survival in colorectal cancer patients. Combining E-cadherin expression levels with TNM staging provides a more precise prediction of patient prognosis and survival, potentially guiding personalized treatment strategies.https://doi.org/10.1186/s12885-025-13539-9Colorectal cancerE-cadherinPrognosisTNM staging |
| spellingShingle | Jae-Ghi Lee Ilkyu Park Hannah Lee Seungyoon Nam Jisup Kim Won-Suk Lee Myunghee Kang Jung Ho Kim Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients BMC Cancer Colorectal cancer E-cadherin Prognosis TNM staging |
| title | Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients |
| title_full | Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients |
| title_fullStr | Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients |
| title_full_unstemmed | Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients |
| title_short | Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients |
| title_sort | integrating e cadherin expression levels with tnm staging for enhanced prognostic prediction in colorectal cancer patients |
| topic | Colorectal cancer E-cadherin Prognosis TNM staging |
| url | https://doi.org/10.1186/s12885-025-13539-9 |
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