Strategies for Structural Genomics Target Selection
We have developed a protein sequence analysis pipeline that ranks proteins as targets for high throughput structure determination. The ranking is designed to maximize both the biological and informational impact of new 3D protein structures solved through the structural genomics initiative. The anal...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.33 |
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| _version_ | 1850172037224464384 |
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| author | Teri Gaasterland |
| author_facet | Teri Gaasterland |
| author_sort | Teri Gaasterland |
| collection | DOAJ |
| description | We have developed a protein sequence analysis pipeline that ranks proteins as targets for high throughput structure determination. The ranking is designed to maximize both the biological and informational impact of new 3D protein structures solved through the structural genomics initiative. The analysis system accepts proteins from multiple genomes as input, builds sequence families based on remote homology, identifies families with one or more solved structures, and ranks the remaining families according to criteria designed to maximize structure determination efficacy, increase the likelihood of a novel fold, and maximize the number of new protein structure models that can be built from a solved structure. |
| format | Article |
| id | doaj-art-a161f4fe4a7142cb9557bb5efe74d196 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a161f4fe4a7142cb9557bb5efe74d1962025-08-20T02:20:09ZengWileyThe Scientific World Journal1537-744X2002-01-012676710.1100/tsw.2002.33Strategies for Structural Genomics Target SelectionTeri Gaasterland0Laboratory of Computational Genomics, Rockefeller University, 1230 York Ave., New York, NY 10021, USAWe have developed a protein sequence analysis pipeline that ranks proteins as targets for high throughput structure determination. The ranking is designed to maximize both the biological and informational impact of new 3D protein structures solved through the structural genomics initiative. The analysis system accepts proteins from multiple genomes as input, builds sequence families based on remote homology, identifies families with one or more solved structures, and ranks the remaining families according to criteria designed to maximize structure determination efficacy, increase the likelihood of a novel fold, and maximize the number of new protein structure models that can be built from a solved structure.http://dx.doi.org/10.1100/tsw.2002.33 |
| spellingShingle | Teri Gaasterland Strategies for Structural Genomics Target Selection The Scientific World Journal |
| title | Strategies for Structural Genomics Target Selection |
| title_full | Strategies for Structural Genomics Target Selection |
| title_fullStr | Strategies for Structural Genomics Target Selection |
| title_full_unstemmed | Strategies for Structural Genomics Target Selection |
| title_short | Strategies for Structural Genomics Target Selection |
| title_sort | strategies for structural genomics target selection |
| url | http://dx.doi.org/10.1100/tsw.2002.33 |
| work_keys_str_mv | AT terigaasterland strategiesforstructuralgenomicstargetselection |