Curative timed NK cell-based immunochemotherapy aborts brain tumour recurrence driven by mesenchymal glioma stem cells

Curative timed NK cell-based immunochemotherapy aborts brain tumour recurrence driven by mesenchymal glioma stem cells

Abstract High grade gliomas (HGG) are incurable brain cancers, where inevitable disease recurrence is driven by tumour-initiating glioma stem cells (GSCs). GSCs survive and expand in the brain after surgery, radiation and temozolomide (TMZ) chemotherapy, amidst weak immune and natural killer (NK) ce...

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Bibliographic Details
Main Authors: Brian Meehan, Lata Adnani, Xianbing Zhu, Nadim Tawil, Delphine Garnier, Ichiro Nakano, Sidong Huang, Janusz Rak
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Acta Neuropathologica Communications
Subjects:
High grade glioma
Glioblastoma
Mesenchymal glioma stem cells
Proneural glioma stem cells
NK cells
Temozolomide
Online Access:https://doi.org/10.1186/s40478-025-01984-3
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