Study on the correlation between carotid plaque calcification types and acute ischemic stroke

IntroductionComputed tomography angiography (CTA) was used to explore the correlation between the calcification types of carotid plaques and ipsilateral acute ischemic stroke. This could provide new insights into the clinical evaluation and treatment of ischemic stroke.MethodsThis study obtained inf...

Full description

Saved in:
Bibliographic Details
Main Authors: Tianyu Chu, Zhongping Guo, Yonggang Zhang, Ying Liu, Yan Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1550014/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1823856999098482688
author Tianyu Chu
Zhongping Guo
Yonggang Zhang
Ying Liu
Yan Gu
author_facet Tianyu Chu
Zhongping Guo
Yonggang Zhang
Ying Liu
Yan Gu
author_sort Tianyu Chu
collection DOAJ
description IntroductionComputed tomography angiography (CTA) was used to explore the correlation between the calcification types of carotid plaques and ipsilateral acute ischemic stroke. This could provide new insights into the clinical evaluation and treatment of ischemic stroke.MethodsThis study obtained information on patients undergoing head and neck CTA examinations at the First People's Hospital of Lianyungang between September 2022 and August 2023 to investigate the clinical differences in baseline data between the acute ischemic stroke and control groups. Patients meeting the inclusion and exclusion criteria were classified into 1 to 6 groups according to their plaque calcification characteristics. The correlation between calcified plaque type and ipsilateral acute ischemic anterior circulation stroke was analyzed using paired sample chi-square and Spearman correlation tests.ResultsBased on the inclusion and exclusion criteria, this study included 589 patients with plaques at the bifurcation of the carotid arteries. In both the acute ischemic stroke and control groups, sex, smoking, alcohol consumption, systolic blood pressure, blood sugar, cholesterol, high-density lipoprotein, and homocysteine levels were statistically significant (p < 0.05). During the Spearman correlation analysis between calcification type and acute stroke (1,178 carotid arteries), different calcification types of plaques were linked with ipsilateral acute anterior circulation stroke with statistically significant differences (p < 0.001). Finally, the chi-squared test of the paired samples showed that the grade of plaque calcification is often higher on the side of acute infarction than on the side without acute infarction, and the difference is statistically significant (p < 0.001).DiscussionCarotid plaque calcification is associated with acute ischemic stroke. Our findings provide novel insights into the study of calcification in carotid atherosclerotic plaques and additional radiological evidence to clinically assess the risk of ischemic stroke.
format Article
id doaj-art-a15eb773fedf4d5f959257dfedca5d31
institution Kabale University
issn 1664-2295
language English
publishDate 2025-02-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Neurology
spelling doaj-art-a15eb773fedf4d5f959257dfedca5d312025-02-12T05:15:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.15500141550014Study on the correlation between carotid plaque calcification types and acute ischemic strokeTianyu ChuZhongping GuoYonggang ZhangYing LiuYan GuIntroductionComputed tomography angiography (CTA) was used to explore the correlation between the calcification types of carotid plaques and ipsilateral acute ischemic stroke. This could provide new insights into the clinical evaluation and treatment of ischemic stroke.MethodsThis study obtained information on patients undergoing head and neck CTA examinations at the First People's Hospital of Lianyungang between September 2022 and August 2023 to investigate the clinical differences in baseline data between the acute ischemic stroke and control groups. Patients meeting the inclusion and exclusion criteria were classified into 1 to 6 groups according to their plaque calcification characteristics. The correlation between calcified plaque type and ipsilateral acute ischemic anterior circulation stroke was analyzed using paired sample chi-square and Spearman correlation tests.ResultsBased on the inclusion and exclusion criteria, this study included 589 patients with plaques at the bifurcation of the carotid arteries. In both the acute ischemic stroke and control groups, sex, smoking, alcohol consumption, systolic blood pressure, blood sugar, cholesterol, high-density lipoprotein, and homocysteine levels were statistically significant (p < 0.05). During the Spearman correlation analysis between calcification type and acute stroke (1,178 carotid arteries), different calcification types of plaques were linked with ipsilateral acute anterior circulation stroke with statistically significant differences (p < 0.001). Finally, the chi-squared test of the paired samples showed that the grade of plaque calcification is often higher on the side of acute infarction than on the side without acute infarction, and the difference is statistically significant (p < 0.001).DiscussionCarotid plaque calcification is associated with acute ischemic stroke. Our findings provide novel insights into the study of calcification in carotid atherosclerotic plaques and additional radiological evidence to clinically assess the risk of ischemic stroke.https://www.frontiersin.org/articles/10.3389/fneur.2025.1550014/fullatherosclerosiscarotid plaquecalcified plaquestrokecomputed tomography angiography
spellingShingle Tianyu Chu
Zhongping Guo
Yonggang Zhang
Ying Liu
Yan Gu
Study on the correlation between carotid plaque calcification types and acute ischemic stroke
Frontiers in Neurology
atherosclerosis
carotid plaque
calcified plaque
stroke
computed tomography angiography
title Study on the correlation between carotid plaque calcification types and acute ischemic stroke
title_full Study on the correlation between carotid plaque calcification types and acute ischemic stroke
title_fullStr Study on the correlation between carotid plaque calcification types and acute ischemic stroke
title_full_unstemmed Study on the correlation between carotid plaque calcification types and acute ischemic stroke
title_short Study on the correlation between carotid plaque calcification types and acute ischemic stroke
title_sort study on the correlation between carotid plaque calcification types and acute ischemic stroke
topic atherosclerosis
carotid plaque
calcified plaque
stroke
computed tomography angiography
url https://www.frontiersin.org/articles/10.3389/fneur.2025.1550014/full
work_keys_str_mv AT tianyuchu studyonthecorrelationbetweencarotidplaquecalcificationtypesandacuteischemicstroke
AT zhongpingguo studyonthecorrelationbetweencarotidplaquecalcificationtypesandacuteischemicstroke
AT yonggangzhang studyonthecorrelationbetweencarotidplaquecalcificationtypesandacuteischemicstroke
AT yingliu studyonthecorrelationbetweencarotidplaquecalcificationtypesandacuteischemicstroke
AT yangu studyonthecorrelationbetweencarotidplaquecalcificationtypesandacuteischemicstroke