A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation

Abstract Background Amniotic membrane transplantation (AMT) is a relatively safe procedure with few complications. Postoperatively, patients are treated with topical antibacterial eye drops. However, even antibacterial drug administration cannot completely prevent antimicrobial-resistant keratitis....

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Main Authors: Yuto Yukari, Toshiki Shimizu, Takahiko Hayashi, Yusuke Hara, Ami Igarashi, Satoru Yamagami
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Ophthalmology
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Online Access:https://doi.org/10.1186/s12886-025-04159-9
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author Yuto Yukari
Toshiki Shimizu
Takahiko Hayashi
Yusuke Hara
Ami Igarashi
Satoru Yamagami
author_facet Yuto Yukari
Toshiki Shimizu
Takahiko Hayashi
Yusuke Hara
Ami Igarashi
Satoru Yamagami
author_sort Yuto Yukari
collection DOAJ
description Abstract Background Amniotic membrane transplantation (AMT) is a relatively safe procedure with few complications. Postoperatively, patients are treated with topical antibacterial eye drops. However, even antibacterial drug administration cannot completely prevent antimicrobial-resistant keratitis. This paper presents a case of Corynebacterium propinquum keratitis associated with AMT. Case presentation An 84-year-old female patient who underwent AMT for bullous keratopathy developed keratitis with colony formation on the transplanted amniotic membrane graft 45 days postoperatively. The colony was scraped, cultured, and identified as C. propinquum using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS). Subsequently, topical treatment improved the infection while relieving the pain. Conclusion To the best of our knowledge, this is the first reported case of C. propinquum keratitis associated with amniotic membrane grafts. Although AMT is a relatively safe procedure with few complications, careful observation is required to diagnose and treat possible postoperative infection. Immunosuppressed patients, including those post-AMT, may suffer from antimicrobial-resistant keratitis, necessitating microbial identification and drug susceptibility testing such as MALDI-TOF–MS.
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issn 1471-2415
language English
publishDate 2025-05-01
publisher BMC
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series BMC Ophthalmology
spelling doaj-art-a15d0b779f1044a0bd2238ce687e24192025-08-20T03:16:33ZengBMCBMC Ophthalmology1471-24152025-05-012511510.1186/s12886-025-04159-9A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantationYuto Yukari0Toshiki Shimizu1Takahiko Hayashi2Yusuke Hara3Ami Igarashi4Satoru Yamagami5Department of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityDepartment of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityDepartment of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityDepartment of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityDepartment of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityDepartment of Ophthalmology, Nihon University Itabashi Hospital, Itabashi CityAbstract Background Amniotic membrane transplantation (AMT) is a relatively safe procedure with few complications. Postoperatively, patients are treated with topical antibacterial eye drops. However, even antibacterial drug administration cannot completely prevent antimicrobial-resistant keratitis. This paper presents a case of Corynebacterium propinquum keratitis associated with AMT. Case presentation An 84-year-old female patient who underwent AMT for bullous keratopathy developed keratitis with colony formation on the transplanted amniotic membrane graft 45 days postoperatively. The colony was scraped, cultured, and identified as C. propinquum using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS). Subsequently, topical treatment improved the infection while relieving the pain. Conclusion To the best of our knowledge, this is the first reported case of C. propinquum keratitis associated with amniotic membrane grafts. Although AMT is a relatively safe procedure with few complications, careful observation is required to diagnose and treat possible postoperative infection. Immunosuppressed patients, including those post-AMT, may suffer from antimicrobial-resistant keratitis, necessitating microbial identification and drug susceptibility testing such as MALDI-TOF–MS.https://doi.org/10.1186/s12886-025-04159-9Amniotic membraneKeratitisC. propinquumMatrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry
spellingShingle Yuto Yukari
Toshiki Shimizu
Takahiko Hayashi
Yusuke Hara
Ami Igarashi
Satoru Yamagami
A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
BMC Ophthalmology
Amniotic membrane
Keratitis
C. propinquum
Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry
title A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
title_full A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
title_fullStr A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
title_full_unstemmed A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
title_short A case of Corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
title_sort case of corynebacterium propinquum microbial keratitis after amniotic membrane transplantation
topic Amniotic membrane
Keratitis
C. propinquum
Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry
url https://doi.org/10.1186/s12886-025-04159-9
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