Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia
IntroductionThe incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels of transmission in the country is important. This study was conducted to evaluate antibody response to Plasmodium falciparum and...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| author | Inke Nadia Diniyanti Lubis Irbah Rea Alvieda Nainggolan Meliani Meliani Beby Syofiani Hasibuan Kumuthamalar Sangaran Kumuthamalar Sangaran Luqman Samsudin Sriwipa Chuangchaiya Paul Cliff Simon Divis Ranti Permatasari Zulkarnain Md Idris |
| author_facet | Inke Nadia Diniyanti Lubis Irbah Rea Alvieda Nainggolan Meliani Meliani Beby Syofiani Hasibuan Kumuthamalar Sangaran Kumuthamalar Sangaran Luqman Samsudin Sriwipa Chuangchaiya Paul Cliff Simon Divis Ranti Permatasari Zulkarnain Md Idris |
| author_sort | Inke Nadia Diniyanti Lubis |
| collection | DOAJ |
| description | IntroductionThe incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels of transmission in the country is important. This study was conducted to evaluate antibody response to Plasmodium falciparum and Plasmodium vivax in an area nearing elimination in North Sumatera Province, Indonesia.MethodsA cross-sectional survey was conducted in Langkat district, North Sumatera Province, in June 2019. Basic demographic data and filter paper blood spots were collected from 339 participants. Antibody responses to two P. falciparum (PfAMA-1 and PfMSP-119) and two P. vivax (PvAMA-1 and PvMSP-119) antigens were measured using indirect enzyme-linked immunosorbent assay (ELISA). Seroconversion rates (SCR) were estimated by fitting a simple reversible catalytic model to seroprevalence data for each antibody. Multiple logistic regression was used to investigate factors associated with exposure.ResultsThe overall malaria seroprevalence was 10.6% for PfAMA-1, 13% for PfMSP-119, 18.6% for PvAMA-1, and 7.4% for PvMSP-119. Seropositive individuals for P. falciparum (PfAMA-1/PfMSP-119) and P. vivax (PvAMA-1/PvMSP-119) were similar at 20.7%, with no significant differences observed between age groups (p > 0.05). Based on the reversible catalytic model, the calculated SCRs indicated a higher level of P. falciparum transmission than P. vivax using all tested antigens. In the adjusted model, only spending nights in the forest was associated with P. vivax seropositivity (odd ratio: 3.93, p < 0.001).ConclusionThe analysis of community-based serological data helps describe the similar levels of P. falciparum and P. vivax transmission in the Langkat district. The use of a serological approach enhances the detection of past exposure, aiding in the identification of epidemiological risk factors and malaria surveillance in low transmission settings in Indonesia. |
| format | Article |
| id | doaj-art-a159aefde58b45aa9ee48539abb0371e |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-a159aefde58b45aa9ee48539abb0371e2025-08-20T02:43:16ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15047411504741Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, IndonesiaInke Nadia Diniyanti Lubis0Irbah Rea Alvieda Nainggolan1Meliani Meliani2Beby Syofiani Hasibuan3Kumuthamalar Sangaran4Kumuthamalar Sangaran5Luqman Samsudin6Sriwipa Chuangchaiya7Paul Cliff Simon Divis8Ranti Permatasari9Zulkarnain Md Idris10Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaFaculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaFaculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaFaculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaNational Public Health Laboratory, Ministry of Health, Sungai Buloh, Selangor, MalaysiaVector-Borne Disease Unit, Lipis District Health Office, Kuala Lipis, Pahang, MalaysiaDepartment of Community Health, Faculty of Public Health, Kasetsart University, Sakon Nakhon, ThailandMalaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, MalaysiaFaculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaIntroductionThe incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels of transmission in the country is important. This study was conducted to evaluate antibody response to Plasmodium falciparum and Plasmodium vivax in an area nearing elimination in North Sumatera Province, Indonesia.MethodsA cross-sectional survey was conducted in Langkat district, North Sumatera Province, in June 2019. Basic demographic data and filter paper blood spots were collected from 339 participants. Antibody responses to two P. falciparum (PfAMA-1 and PfMSP-119) and two P. vivax (PvAMA-1 and PvMSP-119) antigens were measured using indirect enzyme-linked immunosorbent assay (ELISA). Seroconversion rates (SCR) were estimated by fitting a simple reversible catalytic model to seroprevalence data for each antibody. Multiple logistic regression was used to investigate factors associated with exposure.ResultsThe overall malaria seroprevalence was 10.6% for PfAMA-1, 13% for PfMSP-119, 18.6% for PvAMA-1, and 7.4% for PvMSP-119. Seropositive individuals for P. falciparum (PfAMA-1/PfMSP-119) and P. vivax (PvAMA-1/PvMSP-119) were similar at 20.7%, with no significant differences observed between age groups (p > 0.05). Based on the reversible catalytic model, the calculated SCRs indicated a higher level of P. falciparum transmission than P. vivax using all tested antigens. In the adjusted model, only spending nights in the forest was associated with P. vivax seropositivity (odd ratio: 3.93, p < 0.001).ConclusionThe analysis of community-based serological data helps describe the similar levels of P. falciparum and P. vivax transmission in the Langkat district. The use of a serological approach enhances the detection of past exposure, aiding in the identification of epidemiological risk factors and malaria surveillance in low transmission settings in Indonesia.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1504741/fullmalariaP. falciparumP. vivaxserologytransmissionIndonesia |
| spellingShingle | Inke Nadia Diniyanti Lubis Irbah Rea Alvieda Nainggolan Meliani Meliani Beby Syofiani Hasibuan Kumuthamalar Sangaran Kumuthamalar Sangaran Luqman Samsudin Sriwipa Chuangchaiya Paul Cliff Simon Divis Ranti Permatasari Zulkarnain Md Idris Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia Frontiers in Cellular and Infection Microbiology malaria P. falciparum P. vivax serology transmission Indonesia |
| title | Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia |
| title_full | Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia |
| title_fullStr | Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia |
| title_full_unstemmed | Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia |
| title_short | Serology reveals comparable patterns in the transmission intensities of Plasmodium falciparum and Plasmodium vivax in Langkat district, North Sumatera Province, Indonesia |
| title_sort | serology reveals comparable patterns in the transmission intensities of plasmodium falciparum and plasmodium vivax in langkat district north sumatera province indonesia |
| topic | malaria P. falciparum P. vivax serology transmission Indonesia |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1504741/full |
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