Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses
Acute respiratory viral infections (ARIs) represent a significant global health challenge, contributing heavily to worldwide morbidity and mortality rates. Recent efforts to combat ARIs have focused on developing nasal spray formulations that effectively target the nasal mucosa. However, challenges...
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MDPI AG
2025-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/3/112 |
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| author | Seong Ok Park Erdenebileg Uyangaa Yong-Kwang Lee Suk-Hyun Yun Minyeong Yu Hyo Jin Kim Hye Won Cho Hee Won Byeon Chong-Kil Lee Seong Kug Eo |
| author_facet | Seong Ok Park Erdenebileg Uyangaa Yong-Kwang Lee Suk-Hyun Yun Minyeong Yu Hyo Jin Kim Hye Won Cho Hee Won Byeon Chong-Kil Lee Seong Kug Eo |
| author_sort | Seong Ok Park |
| collection | DOAJ |
| description | Acute respiratory viral infections (ARIs) represent a significant global health challenge, contributing heavily to worldwide morbidity and mortality rates. Recent efforts to combat ARIs have focused on developing nasal spray formulations that effectively target the nasal mucosa. However, challenges such as irritation, discomfort, and safety concerns highlight the need for natural, eco-friendly ingredients. In this study, we evaluated the efficacy of solubilized sturgeon oil (SSO), prepared as an oil-in-water nanoemulsion from Siberian sturgeon, as an eco-friendly preventive nasal spray agent against ARIs. Intranasal pre-treatment with SSO effectively inhibited respiratory infections caused by SARS-CoV-2, influenza A virus (IAV), and respiratory syncytial virus (RSV). Additionally, it suppressed viral replication in both nasal and lung tissues. This antiviral effect was linked to reduced pulmonary inflammation, characterized by decreased infiltration of Ly-6C<sup>+</sup> monocytes and Ly-6G<sup>+</sup> neutrophils, along with lower pro-inflammatory cytokine levels. Histopathological analyses confirmed that nasal SSO administration significantly mitigated lung inflammation progression caused by viral infections. Notably, the protective effects of SSO against SARS-CoV-2, IAV, and RSV persisted for at least six hours following nasal application. These findings highlight SSO as a promising eco-friendly and safe candidate for nasal spray formulations, providing a potential frontline defense against ARIs. |
| format | Article |
| id | doaj-art-a15635509cb541e49fc8ef56587c2248 |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-a15635509cb541e49fc8ef56587c22482025-08-20T02:42:26ZengMDPI AGMarine Drugs1660-33972025-03-0123311210.3390/md23030112Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory VirusesSeong Ok Park0Erdenebileg Uyangaa1Yong-Kwang Lee2Suk-Hyun Yun3Minyeong Yu4Hyo Jin Kim5Hye Won Cho6Hee Won Byeon7Chong-Kil Lee8Seong Kug Eo9Bio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBIO R&D Center, Sturgeon Bio Ltd., Co., Cheongju 28581, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaBIO R&D Center, Sturgeon Bio Ltd., Co., Cheongju 28581, Republic of KoreaBio-Safety Research Institute, and Core Facility Center for Zoonosis Research (Core-FCZR), College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of KoreaAcute respiratory viral infections (ARIs) represent a significant global health challenge, contributing heavily to worldwide morbidity and mortality rates. Recent efforts to combat ARIs have focused on developing nasal spray formulations that effectively target the nasal mucosa. However, challenges such as irritation, discomfort, and safety concerns highlight the need for natural, eco-friendly ingredients. In this study, we evaluated the efficacy of solubilized sturgeon oil (SSO), prepared as an oil-in-water nanoemulsion from Siberian sturgeon, as an eco-friendly preventive nasal spray agent against ARIs. Intranasal pre-treatment with SSO effectively inhibited respiratory infections caused by SARS-CoV-2, influenza A virus (IAV), and respiratory syncytial virus (RSV). Additionally, it suppressed viral replication in both nasal and lung tissues. This antiviral effect was linked to reduced pulmonary inflammation, characterized by decreased infiltration of Ly-6C<sup>+</sup> monocytes and Ly-6G<sup>+</sup> neutrophils, along with lower pro-inflammatory cytokine levels. Histopathological analyses confirmed that nasal SSO administration significantly mitigated lung inflammation progression caused by viral infections. Notably, the protective effects of SSO against SARS-CoV-2, IAV, and RSV persisted for at least six hours following nasal application. These findings highlight SSO as a promising eco-friendly and safe candidate for nasal spray formulations, providing a potential frontline defense against ARIs.https://www.mdpi.com/1660-3397/23/3/112solubilized sturgeon oilacute respiratory viral infectionSARS-CoV-2influenza A virusrespiratory syncytial virus |
| spellingShingle | Seong Ok Park Erdenebileg Uyangaa Yong-Kwang Lee Suk-Hyun Yun Minyeong Yu Hyo Jin Kim Hye Won Cho Hee Won Byeon Chong-Kil Lee Seong Kug Eo Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses Marine Drugs solubilized sturgeon oil acute respiratory viral infection SARS-CoV-2 influenza A virus respiratory syncytial virus |
| title | Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses |
| title_full | Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses |
| title_fullStr | Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses |
| title_full_unstemmed | Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses |
| title_short | Exploring the Preventive Potential of Solubilized Sturgeon Oil on Acute Infection with Respiratory Viruses |
| title_sort | exploring the preventive potential of solubilized sturgeon oil on acute infection with respiratory viruses |
| topic | solubilized sturgeon oil acute respiratory viral infection SARS-CoV-2 influenza A virus respiratory syncytial virus |
| url | https://www.mdpi.com/1660-3397/23/3/112 |
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