Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation
Magnesium plays a crucial role in over 300 enzymatic reactions related to energy production, muscle contraction, and nerve function. Given its essential biological functions and increasing prevalence of suboptimal intake, magnesium supplementation has gained attention for its potential health benefi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/14/6/740 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849433037118373888 |
|---|---|
| author | Violeta Cepeda Marina Ródenas-Munar Silvia García Cristina Bouzas Josep A. Tur |
| author_facet | Violeta Cepeda Marina Ródenas-Munar Silvia García Cristina Bouzas Josep A. Tur |
| author_sort | Violeta Cepeda |
| collection | DOAJ |
| description | Magnesium plays a crucial role in over 300 enzymatic reactions related to energy production, muscle contraction, and nerve function. Given its essential biological functions and increasing prevalence of suboptimal intake, magnesium supplementation has gained attention for its potential health benefits, particularly in mitigating oxidative stress and inflammation. This systematic review and meta-analysis aimed to evaluate the antioxidant effects of dietary and supplemental magnesium on several biomarkers related to oxidative stress and inflammation. A systematic search of studies published from 2000 to 2025 identified 28 relevant articles, including both animal and human studies. The meta-analysis assessed the effects of magnesium supplementation on oxidative stress biomarkers such as nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), and C-reactive protein (CRP). While results showed a statistically significant reduction in CRP levels, suggesting an anti-inflammatory effect, no conclusive impact on oxidative stress biomarkers was observed. The findings highlight magnesium’s potential role in inflammation regulation, though its direct antioxidant effects remain uncertain. Further high-quality clinical trials are needed to clarify the impact of magnesium supplementation on oxidative stress and to explore its broader health implications. |
| format | Article |
| id | doaj-art-a154dc2cea0f4ab688578a41808fec90 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-a154dc2cea0f4ab688578a41808fec902025-08-20T03:27:11ZengMDPI AGAntioxidants2076-39212025-06-0114674010.3390/antiox14060740Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and InflammationVioleta Cepeda0Marina Ródenas-Munar1Silvia García2Cristina Bouzas3Josep A. Tur4Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, SpainResearch Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Guillem Colom Bldg, Campus, E-07122 Palma de Mallorca, SpainMagnesium plays a crucial role in over 300 enzymatic reactions related to energy production, muscle contraction, and nerve function. Given its essential biological functions and increasing prevalence of suboptimal intake, magnesium supplementation has gained attention for its potential health benefits, particularly in mitigating oxidative stress and inflammation. This systematic review and meta-analysis aimed to evaluate the antioxidant effects of dietary and supplemental magnesium on several biomarkers related to oxidative stress and inflammation. A systematic search of studies published from 2000 to 2025 identified 28 relevant articles, including both animal and human studies. The meta-analysis assessed the effects of magnesium supplementation on oxidative stress biomarkers such as nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), and C-reactive protein (CRP). While results showed a statistically significant reduction in CRP levels, suggesting an anti-inflammatory effect, no conclusive impact on oxidative stress biomarkers was observed. The findings highlight magnesium’s potential role in inflammation regulation, though its direct antioxidant effects remain uncertain. Further high-quality clinical trials are needed to clarify the impact of magnesium supplementation on oxidative stress and to explore its broader health implications.https://www.mdpi.com/2076-3921/14/6/740Mg supplementationantioxidantinflammationoxidative stressmeta-analysis |
| spellingShingle | Violeta Cepeda Marina Ródenas-Munar Silvia García Cristina Bouzas Josep A. Tur Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation Antioxidants Mg supplementation antioxidant inflammation oxidative stress meta-analysis |
| title | Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation |
| title_full | Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation |
| title_fullStr | Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation |
| title_full_unstemmed | Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation |
| title_short | Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation |
| title_sort | unlocking the power of magnesium a systematic review and meta analysis regarding its role in oxidative stress and inflammation |
| topic | Mg supplementation antioxidant inflammation oxidative stress meta-analysis |
| url | https://www.mdpi.com/2076-3921/14/6/740 |
| work_keys_str_mv | AT violetacepeda unlockingthepowerofmagnesiumasystematicreviewandmetaanalysisregardingitsroleinoxidativestressandinflammation AT marinarodenasmunar unlockingthepowerofmagnesiumasystematicreviewandmetaanalysisregardingitsroleinoxidativestressandinflammation AT silviagarcia unlockingthepowerofmagnesiumasystematicreviewandmetaanalysisregardingitsroleinoxidativestressandinflammation AT cristinabouzas unlockingthepowerofmagnesiumasystematicreviewandmetaanalysisregardingitsroleinoxidativestressandinflammation AT josepatur unlockingthepowerofmagnesiumasystematicreviewandmetaanalysisregardingitsroleinoxidativestressandinflammation |