Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis
Background: The distribution of arboviruses in endemic regions is experiencing a significant shift, along with the re-emergence of Oropouche virus (OROV) as a significant pathogen, characterized by dynamic vector-borne transmission. Despite growing public health relevance, OROV remains insufficientl...
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Elsevier
2025-09-01
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| Series: | Travel Medicine and Infectious Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893925000833 |
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| author | Karolaine Santos Teixeira Hillquias Monteiro Moreira Tárcio Peixoto Roca Edilene Pereira Pimentel Jackson Alves da Silva Queiroz Jessiane Rodrigues Ribeiro Ana Maisa Passos-Silva Adrhyan Araújo Kátia Ingred da Silva Maia Felipe Gomes Naveca Ighor Arantes Gonzalo Bello Jansen Fernandes de Medeiros Marco Aurelio Krieger Juan Miguel Villalobos Salcedo Rita de Cássia Pontello Rampazzo Deusilene Vieira |
| author_facet | Karolaine Santos Teixeira Hillquias Monteiro Moreira Tárcio Peixoto Roca Edilene Pereira Pimentel Jackson Alves da Silva Queiroz Jessiane Rodrigues Ribeiro Ana Maisa Passos-Silva Adrhyan Araújo Kátia Ingred da Silva Maia Felipe Gomes Naveca Ighor Arantes Gonzalo Bello Jansen Fernandes de Medeiros Marco Aurelio Krieger Juan Miguel Villalobos Salcedo Rita de Cássia Pontello Rampazzo Deusilene Vieira |
| author_sort | Karolaine Santos Teixeira |
| collection | DOAJ |
| description | Background: The distribution of arboviruses in endemic regions is experiencing a significant shift, along with the re-emergence of Oropouche virus (OROV) as a significant pathogen, characterized by dynamic vector-borne transmission. Despite growing public health relevance, OROV remains insufficiently characterized, with limited comprehensive genomic and epidemiological data. This knowledge gap affects the accuracy of diagnostic approaches and limits the effectiveness of surveillance and control strategies. This study aimed to characterize the re-emergence of OROV in endemic regions, elucidate its epidemiological distribution, and clarify the epidemiological distribution of OROV and assess its impact on diagnostic strategies and surveillance for acute febrile illness. Methods: Between January and July 2024, a total of 869 individuals with malaria-negative acute febrile illness were screened for dengue, Zika, and chikungunya viruses. Duplex RT-qPCR assays were subsequently employed to detect Mayaro and Oropouche viruses. Spatiotemporal and geospatial analyses were conducted to assess the distribution of OROV in relation to environmental factors. Findings: Among the participants, 35 % tested positive for OROV, with cases predominantly concentrated in forest and riverine areas. Considering that the significant increase in the number of cases occurred in a short space of time, the results highlight the urgent need to strengthen genomic and epidemiological surveillance to tackle emerging arboviral threats. |
| format | Article |
| id | doaj-art-a151db714a3d4446abae0d4e056e8518 |
| institution | DOAJ |
| issn | 1873-0442 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
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| series | Travel Medicine and Infectious Disease |
| spelling | doaj-art-a151db714a3d4446abae0d4e056e85182025-08-20T02:58:27ZengElsevierTravel Medicine and Infectious Disease1873-04422025-09-016710287710.1016/j.tmaid.2025.102877Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysisKarolaine Santos Teixeira0Hillquias Monteiro Moreira1Tárcio Peixoto Roca2Edilene Pereira Pimentel3Jackson Alves da Silva Queiroz4Jessiane Rodrigues Ribeiro5Ana Maisa Passos-Silva6Adrhyan Araújo7Kátia Ingred da Silva Maia8Felipe Gomes Naveca9Ighor Arantes10Gonzalo Bello11Jansen Fernandes de Medeiros12Marco Aurelio Krieger13Juan Miguel Villalobos Salcedo14Rita de Cássia Pontello Rampazzo15Deusilene Vieira16Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical, CEPEM, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical, CEPEM, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, BrazilNúcleo de Vigilância de Vírus Emergentes, Reemergentes ou Negligenciados – ViVER/EDTA. Instituto Leônidas e Maria Deane, Fiocruz, Manaus, AM, Brazil; Laboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, BrazilLaboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, BrazilLaboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, BrazilInstituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, Brazil; Laboratório de Entomologia, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, BrazilInstituto Carlos Chagas - ICC, Fundação Oswaldo Cruz, Paraná, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical, CEPEM, Porto Velho, RO, Brazil; Universidade Federal de Rondônia - UNIR, Porto Velho, RO, BrazilReddot Bio, Florianópolis, Santa Catarina, BrazilLaboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia - FIOCRUZ/RO, Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia - UNIR, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical, CEPEM, Porto Velho, RO, Brazil; Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental – INCT-EpiAmO, Porto Velho, RO, Brazil; Corresponding author. Fiocruz Rondônia, Rua da Beira, 7176, Bairro Lagoa, 76812-245, Porto Velho, Rondonia, Brazil.Background: The distribution of arboviruses in endemic regions is experiencing a significant shift, along with the re-emergence of Oropouche virus (OROV) as a significant pathogen, characterized by dynamic vector-borne transmission. Despite growing public health relevance, OROV remains insufficiently characterized, with limited comprehensive genomic and epidemiological data. This knowledge gap affects the accuracy of diagnostic approaches and limits the effectiveness of surveillance and control strategies. This study aimed to characterize the re-emergence of OROV in endemic regions, elucidate its epidemiological distribution, and clarify the epidemiological distribution of OROV and assess its impact on diagnostic strategies and surveillance for acute febrile illness. Methods: Between January and July 2024, a total of 869 individuals with malaria-negative acute febrile illness were screened for dengue, Zika, and chikungunya viruses. Duplex RT-qPCR assays were subsequently employed to detect Mayaro and Oropouche viruses. Spatiotemporal and geospatial analyses were conducted to assess the distribution of OROV in relation to environmental factors. Findings: Among the participants, 35 % tested positive for OROV, with cases predominantly concentrated in forest and riverine areas. Considering that the significant increase in the number of cases occurred in a short space of time, the results highlight the urgent need to strengthen genomic and epidemiological surveillance to tackle emerging arboviral threats.http://www.sciencedirect.com/science/article/pii/S1477893925000833Oropouche virusOutbreakGenomic surveillancePhylogeny |
| spellingShingle | Karolaine Santos Teixeira Hillquias Monteiro Moreira Tárcio Peixoto Roca Edilene Pereira Pimentel Jackson Alves da Silva Queiroz Jessiane Rodrigues Ribeiro Ana Maisa Passos-Silva Adrhyan Araújo Kátia Ingred da Silva Maia Felipe Gomes Naveca Ighor Arantes Gonzalo Bello Jansen Fernandes de Medeiros Marco Aurelio Krieger Juan Miguel Villalobos Salcedo Rita de Cássia Pontello Rampazzo Deusilene Vieira Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis Travel Medicine and Infectious Disease Oropouche virus Outbreak Genomic surveillance Phylogeny |
| title | Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis |
| title_full | Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis |
| title_fullStr | Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis |
| title_full_unstemmed | Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis |
| title_short | Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis |
| title_sort | reemergence of oropouche in the brazilian amazon a phylodynamic and phylogenetic analysis |
| topic | Oropouche virus Outbreak Genomic surveillance Phylogeny |
| url | http://www.sciencedirect.com/science/article/pii/S1477893925000833 |
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