Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study
Background: The aim of the study was to compare trastuzumab-based neoadjuvant therapy (NAT) with adjuvant therapy (AT) in a register-based cohort of Swedish patients with primary operable human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Patients and methods: The Swedish nation...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | ESMO Real World Data and Digital Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949820124000717 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850175696740024320 |
|---|---|
| author | S. Hosseini-Mellner Å. Wickberg E. Olsson A. Karakatsanis A. Valachis |
| author_facet | S. Hosseini-Mellner Å. Wickberg E. Olsson A. Karakatsanis A. Valachis |
| author_sort | S. Hosseini-Mellner |
| collection | DOAJ |
| description | Background: The aim of the study was to compare trastuzumab-based neoadjuvant therapy (NAT) with adjuvant therapy (AT) in a register-based cohort of Swedish patients with primary operable human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Patients and methods: The Swedish nationwide research database BCBaSe 3.0 was used to identify eligible patients with primary operable HER2-positive breast cancer treated with either NAT or AT between 2008 and 2019. To mitigate confounding by indication bias, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were applied. Results: In total, 7258 patients with primary operable HER2-positive breast cancer were identified; 1789 (24.6%) received NAT and 5469 (75.4%), AT. After 1 : 1 PSM, 1258 patients in each therapeutic strategy were available for comparisons. No statistically significant differences between NAT and AT were observed [hazard ratio (HR) for distant disease-free survival 0.97, 95% confidence (CI) 0.72-1.30; HR for breast cancer-specific survival (BCSS) 0.69, 95% CI 0.45-1.07; HR for overall (OS) 0.72, 95% CI 0.50-1.05]. In subgroup analysis, NAT resulted in better BCSS (HR 0.44, 95% CI 0.22-0.89) and OS (HR 0.49, 95% CI 0.29-0.90) in patients with clinical node positivity (cN+) at diagnosis. Conclusion: The study shows an equivalence of NAT and AT in terms of prognosis for patients with operable HER2-positive disease whereas a potential benefit of NAT in patients with cN+ is implied. Considering the emerging treatment strategies in the neoadjuvant setting for HER2-positive breast cancer that are not reflected in the study cohort, NAT should be considered as the strategy with a higher possibility of improving long-term prognosis for patients with HER2-positive disease. |
| format | Article |
| id | doaj-art-a15165a0ed74409db9cec283b0f117c8 |
| institution | OA Journals |
| issn | 2949-8201 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ESMO Real World Data and Digital Oncology |
| spelling | doaj-art-a15165a0ed74409db9cec283b0f117c82025-08-20T02:19:23ZengElsevierESMO Real World Data and Digital Oncology2949-82012024-12-01610009310.1016/j.esmorw.2024.100093Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort studyS. Hosseini-Mellner0Å. Wickberg1E. Olsson2A. Karakatsanis3A. Valachis4School of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Surgery, Stockholm South General Hospital, Stockholm, SwedenDepartment of Surgery, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, SwedenDepartment of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, SwedenDepartment of Surgical Sciences, Uppsala University Hospital, Uppsala University, Uppsala, Sweden; Section for Breast Surgery, Department of Surgery, Uppsala University Hospital, Uppsala, SwedenDepartment of Oncology, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, Sweden; Correspondence to: Prof. Antonis Valachis, Department of Oncology, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, 70182, Örebro, Sweden. Tel: 0046735617691Background: The aim of the study was to compare trastuzumab-based neoadjuvant therapy (NAT) with adjuvant therapy (AT) in a register-based cohort of Swedish patients with primary operable human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Patients and methods: The Swedish nationwide research database BCBaSe 3.0 was used to identify eligible patients with primary operable HER2-positive breast cancer treated with either NAT or AT between 2008 and 2019. To mitigate confounding by indication bias, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were applied. Results: In total, 7258 patients with primary operable HER2-positive breast cancer were identified; 1789 (24.6%) received NAT and 5469 (75.4%), AT. After 1 : 1 PSM, 1258 patients in each therapeutic strategy were available for comparisons. No statistically significant differences between NAT and AT were observed [hazard ratio (HR) for distant disease-free survival 0.97, 95% confidence (CI) 0.72-1.30; HR for breast cancer-specific survival (BCSS) 0.69, 95% CI 0.45-1.07; HR for overall (OS) 0.72, 95% CI 0.50-1.05]. In subgroup analysis, NAT resulted in better BCSS (HR 0.44, 95% CI 0.22-0.89) and OS (HR 0.49, 95% CI 0.29-0.90) in patients with clinical node positivity (cN+) at diagnosis. Conclusion: The study shows an equivalence of NAT and AT in terms of prognosis for patients with operable HER2-positive disease whereas a potential benefit of NAT in patients with cN+ is implied. Considering the emerging treatment strategies in the neoadjuvant setting for HER2-positive breast cancer that are not reflected in the study cohort, NAT should be considered as the strategy with a higher possibility of improving long-term prognosis for patients with HER2-positive disease.http://www.sciencedirect.com/science/article/pii/S2949820124000717breast cancerHER2-positiveneoadjuvantadjuvantreal-world evidence |
| spellingShingle | S. Hosseini-Mellner Å. Wickberg E. Olsson A. Karakatsanis A. Valachis Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study ESMO Real World Data and Digital Oncology breast cancer HER2-positive neoadjuvant adjuvant real-world evidence |
| title | Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study |
| title_full | Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study |
| title_fullStr | Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study |
| title_full_unstemmed | Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study |
| title_short | Neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with HER2-positive breast cancer: a register-based cohort study |
| title_sort | neoadjuvant compared to adjuvant chemotherapy combined with trastuzumab in patients with her2 positive breast cancer a register based cohort study |
| topic | breast cancer HER2-positive neoadjuvant adjuvant real-world evidence |
| url | http://www.sciencedirect.com/science/article/pii/S2949820124000717 |
| work_keys_str_mv | AT shosseinimellner neoadjuvantcomparedtoadjuvantchemotherapycombinedwithtrastuzumabinpatientswithher2positivebreastcanceraregisterbasedcohortstudy AT awickberg neoadjuvantcomparedtoadjuvantchemotherapycombinedwithtrastuzumabinpatientswithher2positivebreastcanceraregisterbasedcohortstudy AT eolsson neoadjuvantcomparedtoadjuvantchemotherapycombinedwithtrastuzumabinpatientswithher2positivebreastcanceraregisterbasedcohortstudy AT akarakatsanis neoadjuvantcomparedtoadjuvantchemotherapycombinedwithtrastuzumabinpatientswithher2positivebreastcanceraregisterbasedcohortstudy AT avalachis neoadjuvantcomparedtoadjuvantchemotherapycombinedwithtrastuzumabinpatientswithher2positivebreastcanceraregisterbasedcohortstudy |