The status of serum 25(OH)D levels is related to breast cancer
Aim: Breast cancer is the second most common cancer among women and the leading cause of cancer-related mortality in this population. Numerous factors have been identified as either risk factors or protective factors for breast cancer. However, the role of Vitamin D (Vit. D) in breast cancer remains...
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| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294225000085 |
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| author | Mohammad Momivand Mahta Razaghi Farshid Mohammadi Edris Hoseinzadeh Roya Najafi-Vosough |
| author_facet | Mohammad Momivand Mahta Razaghi Farshid Mohammadi Edris Hoseinzadeh Roya Najafi-Vosough |
| author_sort | Mohammad Momivand |
| collection | DOAJ |
| description | Aim: Breast cancer is the second most common cancer among women and the leading cause of cancer-related mortality in this population. Numerous factors have been identified as either risk factors or protective factors for breast cancer. However, the role of Vitamin D (Vit. D) in breast cancer remains contentious, with conflicting findings in the literature. The present study aimed to compare serum Vit. D levels between women with and without breast cancer. Methods: This cross-sectional study included 40 women diagnosed with breast cancer, referred to the Mahdia Hamadan Radiotherapy Center in 2022. These participants were matched with 40 age- and Vit. D serum level-matched women without breast cancer. Serum Vit. D levels were measured using the ELISA method. Statistical analysis was performed using SPSS version 26, with a significance threshold set at a 95% confidence level. Results: The mean ± standard deviation of serum Vit. D levels in women with and without breast cancer were 31.9 ± 28.27 ng/mL and 37.98 ± 15.89 ng/mL, respectively (P = 0.024). The prevalence of Vit. D insufficiency was 50% in the breast cancer group and 27.5% in the control group, while 50% of the breast cancer group and 72.5% of the control group had sufficient Vit. D levels (P = 0.008). In women with breast cancer, lower Vit. D levels were significantly associated with lower educational (P < 0.001), economic (P < 0.001), and social status (P < 0.001). A weak positive correlation was observed between serum Vit. D levels and patient age (r = 0.162, P = 0.152). Conclusion: The significant difference in serum Vit. D levels between women with and without breast cancer suggests that Vit. D deficiency may be associated with breast cancer risk. These findings support the hypothesis that improving Vit. D status in women could potentially reduce the incidence of breast cancer. |
| format | Article |
| id | doaj-art-a14c2c85816c4539b7ccec1742176802 |
| institution | Kabale University |
| issn | 2468-2942 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj-art-a14c2c85816c4539b7ccec17421768022025-02-09T05:00:48ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0142100870The status of serum 25(OH)D levels is related to breast cancerMohammad Momivand0Mahta Razaghi1Farshid Mohammadi2Edris Hoseinzadeh3Roya Najafi-Vosough4Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, IranClinical Research Development Unit of Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran; Corresponding authors.Clinical Research Development Unit of Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, Iran; Corresponding authors.Environmental Health Engineering Department, Saveh University of Medical Sciences, Saveh, IranDepartment of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IranAim: Breast cancer is the second most common cancer among women and the leading cause of cancer-related mortality in this population. Numerous factors have been identified as either risk factors or protective factors for breast cancer. However, the role of Vitamin D (Vit. D) in breast cancer remains contentious, with conflicting findings in the literature. The present study aimed to compare serum Vit. D levels between women with and without breast cancer. Methods: This cross-sectional study included 40 women diagnosed with breast cancer, referred to the Mahdia Hamadan Radiotherapy Center in 2022. These participants were matched with 40 age- and Vit. D serum level-matched women without breast cancer. Serum Vit. D levels were measured using the ELISA method. Statistical analysis was performed using SPSS version 26, with a significance threshold set at a 95% confidence level. Results: The mean ± standard deviation of serum Vit. D levels in women with and without breast cancer were 31.9 ± 28.27 ng/mL and 37.98 ± 15.89 ng/mL, respectively (P = 0.024). The prevalence of Vit. D insufficiency was 50% in the breast cancer group and 27.5% in the control group, while 50% of the breast cancer group and 72.5% of the control group had sufficient Vit. D levels (P = 0.008). In women with breast cancer, lower Vit. D levels were significantly associated with lower educational (P < 0.001), economic (P < 0.001), and social status (P < 0.001). A weak positive correlation was observed between serum Vit. D levels and patient age (r = 0.162, P = 0.152). Conclusion: The significant difference in serum Vit. D levels between women with and without breast cancer suggests that Vit. D deficiency may be associated with breast cancer risk. These findings support the hypothesis that improving Vit. D status in women could potentially reduce the incidence of breast cancer.http://www.sciencedirect.com/science/article/pii/S2468294225000085Breast cancerVitamin DRadiotherapyVitamin D deficiencyHamadan |
| spellingShingle | Mohammad Momivand Mahta Razaghi Farshid Mohammadi Edris Hoseinzadeh Roya Najafi-Vosough The status of serum 25(OH)D levels is related to breast cancer Cancer Treatment and Research Communications Breast cancer Vitamin D Radiotherapy Vitamin D deficiency Hamadan |
| title | The status of serum 25(OH)D levels is related to breast cancer |
| title_full | The status of serum 25(OH)D levels is related to breast cancer |
| title_fullStr | The status of serum 25(OH)D levels is related to breast cancer |
| title_full_unstemmed | The status of serum 25(OH)D levels is related to breast cancer |
| title_short | The status of serum 25(OH)D levels is related to breast cancer |
| title_sort | status of serum 25 oh d levels is related to breast cancer |
| topic | Breast cancer Vitamin D Radiotherapy Vitamin D deficiency Hamadan |
| url | http://www.sciencedirect.com/science/article/pii/S2468294225000085 |
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