Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization
Background. To compare visual outcomes and spectral-domain optical coherence tomography results following intravitreal ranibizumab treatment for early and mid-idiopathic choroidal neovascularization (ICNV). Methods. This retrospective, case-controlled study examined 44 patients with ICNV in one eye...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/382702 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849398606006583296 |
|---|---|
| author | Chuanfeng Fan Qiang Ji Yu Wang Xiangwen Shu Juan Xie |
| author_facet | Chuanfeng Fan Qiang Ji Yu Wang Xiangwen Shu Juan Xie |
| author_sort | Chuanfeng Fan |
| collection | DOAJ |
| description | Background. To compare visual outcomes and spectral-domain optical coherence tomography results following intravitreal ranibizumab treatment for early and mid-idiopathic choroidal neovascularization (ICNV). Methods. This retrospective, case-controlled study examined 44 patients with ICNV in one eye initially treated with intravitreal ranibizumab (0.5 mg). Further intravitreal treatments were administered as necessary. Patients were divided into two groups according to disease duration, that is, ≤3 months or 3–6 months (early and mid-groups), and the data were compared. Results. All patients completed at least 12 months of follow-up. Significant differences were observed between the groups in best-corrected visual acuity and in central macular thickness (CMT) reduction at all five follow-up visits. At the last follow-up (12 months), 19 early group eyes (79.1%) and 10 mid group eyes (50.0%) had statistically significant visual gains of >15 early treatment diabetic retinopathy study (ETDRS) letters (χ2=4.130, P=0.042). The mean number of injections was significantly higher (P=0.0001) in the mid group (2.53±1.76) than in the early group (1.22±1.01). Conclusions. Early intravitreal ranibizumab for ICNV can result in better visual prognoses, more obvious decreases in CMT, and fewer injections. |
| format | Article |
| id | doaj-art-a145e37fa6a042d8a77c5f1c92a18ae3 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a145e37fa6a042d8a77c5f1c92a18ae32025-08-20T03:38:34ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/382702382702Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal NeovascularizationChuanfeng Fan0Qiang Ji1Yu Wang2Xiangwen Shu3Juan Xie4Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaDepartment of Ophthalmology, The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaDepartment of Ophthalmology, The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaDepartment of Ophthalmology, The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaDepartment of Ophthalmology, The Second People's Hospital of Jinan, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaBackground. To compare visual outcomes and spectral-domain optical coherence tomography results following intravitreal ranibizumab treatment for early and mid-idiopathic choroidal neovascularization (ICNV). Methods. This retrospective, case-controlled study examined 44 patients with ICNV in one eye initially treated with intravitreal ranibizumab (0.5 mg). Further intravitreal treatments were administered as necessary. Patients were divided into two groups according to disease duration, that is, ≤3 months or 3–6 months (early and mid-groups), and the data were compared. Results. All patients completed at least 12 months of follow-up. Significant differences were observed between the groups in best-corrected visual acuity and in central macular thickness (CMT) reduction at all five follow-up visits. At the last follow-up (12 months), 19 early group eyes (79.1%) and 10 mid group eyes (50.0%) had statistically significant visual gains of >15 early treatment diabetic retinopathy study (ETDRS) letters (χ2=4.130, P=0.042). The mean number of injections was significantly higher (P=0.0001) in the mid group (2.53±1.76) than in the early group (1.22±1.01). Conclusions. Early intravitreal ranibizumab for ICNV can result in better visual prognoses, more obvious decreases in CMT, and fewer injections.http://dx.doi.org/10.1155/2014/382702 |
| spellingShingle | Chuanfeng Fan Qiang Ji Yu Wang Xiangwen Shu Juan Xie Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization Journal of Ophthalmology |
| title | Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization |
| title_full | Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization |
| title_fullStr | Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization |
| title_full_unstemmed | Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization |
| title_short | Clinical Efficacy of Intravitreal Ranibizumab in Early and Mid-Idiopathic Choroidal Neovascularization |
| title_sort | clinical efficacy of intravitreal ranibizumab in early and mid idiopathic choroidal neovascularization |
| url | http://dx.doi.org/10.1155/2014/382702 |
| work_keys_str_mv | AT chuanfengfan clinicalefficacyofintravitrealranibizumabinearlyandmididiopathicchoroidalneovascularization AT qiangji clinicalefficacyofintravitrealranibizumabinearlyandmididiopathicchoroidalneovascularization AT yuwang clinicalefficacyofintravitrealranibizumabinearlyandmididiopathicchoroidalneovascularization AT xiangwenshu clinicalefficacyofintravitrealranibizumabinearlyandmididiopathicchoroidalneovascularization AT juanxie clinicalefficacyofintravitrealranibizumabinearlyandmididiopathicchoroidalneovascularization |