Early-Onset Candidemia in Adult Intensive Care Units
Candidemia is a significant cause of morbidity and mortality among critically ill patients. Early-onset candidemia is characterized by occurring within the first seven days after admission to the Intensive Care Unit and presents several important challenges regarding its management. Risk factors may...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/11/1402 |
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| author | Christina Mouratidou Kalliopi Tsakiri Vasiliki Dourliou Alexandra Marneri Maria Stougianni Efstathios Pavlidis |
| author_facet | Christina Mouratidou Kalliopi Tsakiri Vasiliki Dourliou Alexandra Marneri Maria Stougianni Efstathios Pavlidis |
| author_sort | Christina Mouratidou |
| collection | DOAJ |
| description | Candidemia is a significant cause of morbidity and mortality among critically ill patients. Early-onset candidemia is characterized by occurring within the first seven days after admission to the Intensive Care Unit and presents several important challenges regarding its management. Risk factors may vary among patients with early- and late-onset infection, while clinical manifestations are generally non-specific and covered by the underlying disease and co-morbidities. Diagnosis and appropriate therapy are frequently delayed, with a high risk of progression to invasive, deep-seated infections, leading to rapid clinical deterioration. Management strategies to optimize the approach for patients with early-onset candidemia include the use of both conventional and novel diagnostic techniques, the initiation of appropriate antifungal therapy, administration of an adequate dose, daily evaluation of clinical response, de-escalation treatment whenever possible, and early discontinuation. Incorporating an antifungal stewardship program in clinical practice is essential in order to achieve the best clinical outcomes. Based on a review and analysis of the available literature, this article provides a thorough update on the risk factors, clinical characteristics, diagnostic methods, and management of early-onset candidemia in adult critically ill patients. |
| format | Article |
| id | doaj-art-a142afb70e284bb5955e184a49b988ed |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-a142afb70e284bb5955e184a49b988ed2025-08-20T02:33:01ZengMDPI AGDiagnostics2075-44182025-05-011511140210.3390/diagnostics15111402Early-Onset Candidemia in Adult Intensive Care UnitsChristina Mouratidou0Kalliopi Tsakiri1Vasiliki Dourliou2Alexandra Marneri3Maria Stougianni4Efstathios Pavlidis5Department of Adult Intensive Care Unit, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceDepartment of Adult Intensive Care Unit, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceDepartment of Adult Intensive Care Unit, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceDepartment of Adult Intensive Care Unit, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceDepartment of Adult Intensive Care Unit, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceSecond Propedeutical Department of Surgery, Medical School, Aristotle University of Thessaloniki, Ippokrateio General Hospital, 54642 Thessaloniki, GreeceCandidemia is a significant cause of morbidity and mortality among critically ill patients. Early-onset candidemia is characterized by occurring within the first seven days after admission to the Intensive Care Unit and presents several important challenges regarding its management. Risk factors may vary among patients with early- and late-onset infection, while clinical manifestations are generally non-specific and covered by the underlying disease and co-morbidities. Diagnosis and appropriate therapy are frequently delayed, with a high risk of progression to invasive, deep-seated infections, leading to rapid clinical deterioration. Management strategies to optimize the approach for patients with early-onset candidemia include the use of both conventional and novel diagnostic techniques, the initiation of appropriate antifungal therapy, administration of an adequate dose, daily evaluation of clinical response, de-escalation treatment whenever possible, and early discontinuation. Incorporating an antifungal stewardship program in clinical practice is essential in order to achieve the best clinical outcomes. Based on a review and analysis of the available literature, this article provides a thorough update on the risk factors, clinical characteristics, diagnostic methods, and management of early-onset candidemia in adult critically ill patients.https://www.mdpi.com/2075-4418/15/11/1402early-onset candidemia<i>Candida</i> speciesintensive care unitcritically illadult patientsantifungal agents |
| spellingShingle | Christina Mouratidou Kalliopi Tsakiri Vasiliki Dourliou Alexandra Marneri Maria Stougianni Efstathios Pavlidis Early-Onset Candidemia in Adult Intensive Care Units Diagnostics early-onset candidemia <i>Candida</i> species intensive care unit critically ill adult patients antifungal agents |
| title | Early-Onset Candidemia in Adult Intensive Care Units |
| title_full | Early-Onset Candidemia in Adult Intensive Care Units |
| title_fullStr | Early-Onset Candidemia in Adult Intensive Care Units |
| title_full_unstemmed | Early-Onset Candidemia in Adult Intensive Care Units |
| title_short | Early-Onset Candidemia in Adult Intensive Care Units |
| title_sort | early onset candidemia in adult intensive care units |
| topic | early-onset candidemia <i>Candida</i> species intensive care unit critically ill adult patients antifungal agents |
| url | https://www.mdpi.com/2075-4418/15/11/1402 |
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