Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report
Here, we review the latest available studies on using surfactant lavage in newborns with severe manifestations of meconium aspiration syndrome (MAS), illustrated by a representative clinical case. Meconium-stained amniotic fluid may be found in 8-20 % of all births, with the incidence reaching 23-52...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2024-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/2114 |
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| author | A. V. Mostovoi A. L. Karpova I. V. Popov L. A. Anikeeva N. Yu. Karpov |
| author_facet | A. V. Mostovoi A. L. Karpova I. V. Popov L. A. Anikeeva N. Yu. Karpov |
| author_sort | A. V. Mostovoi |
| collection | DOAJ |
| description | Here, we review the latest available studies on using surfactant lavage in newborns with severe manifestations of meconium aspiration syndrome (MAS), illustrated by a representative clinical case. Meconium-stained amniotic fluid may be found in 8-20 % of all births, with the incidence reaching 23-52 % after a full 42 weeks of gestation. From 2 to 9 % of newborns with meconium-stained amniotic fluid subsequently develop MAS clinical signs. About a third of newborns with MAS require tracheal intubation and mechanical ventilation. MAS-related mortality rate due to severe injuries of the lung parenchyma and the development of pulmonary hypertension, can exceed 20 %. Other complications, including air leak syndrome (ALS), occur in 10-30 % of children with MAS. Surfactant lavage may be one of the clinical tools that avoids extracorporeal membrane oxygenation (ECMO) in severe MAS cases. This clinical observation is also of interest because a mature, even post-term newborn with MAS subsequently developed a typical bronchopulmonary dysplasia (BPD), which required proper treatment. |
| format | Article |
| id | doaj-art-a13ef6cc9cac474f9ca2efb54774c9a7 |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-a13ef6cc9cac474f9ca2efb54774c9a72025-08-20T03:57:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942024-09-0118458159510.17749/2313-7347/ob.gyn.rep.2024.533899Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case reportA. V. Mostovoi0A. L. Karpova1I. V. Popov2L. A. Anikeeva3N. Yu. Karpov4Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation; Yaroslavl State Medical University, Health Ministry of Russian FederationVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation; Yaroslavl State Medical University, Health Ministry of Russian FederationVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentTutaev Central District HospitalHere, we review the latest available studies on using surfactant lavage in newborns with severe manifestations of meconium aspiration syndrome (MAS), illustrated by a representative clinical case. Meconium-stained amniotic fluid may be found in 8-20 % of all births, with the incidence reaching 23-52 % after a full 42 weeks of gestation. From 2 to 9 % of newborns with meconium-stained amniotic fluid subsequently develop MAS clinical signs. About a third of newborns with MAS require tracheal intubation and mechanical ventilation. MAS-related mortality rate due to severe injuries of the lung parenchyma and the development of pulmonary hypertension, can exceed 20 %. Other complications, including air leak syndrome (ALS), occur in 10-30 % of children with MAS. Surfactant lavage may be one of the clinical tools that avoids extracorporeal membrane oxygenation (ECMO) in severe MAS cases. This clinical observation is also of interest because a mature, even post-term newborn with MAS subsequently developed a typical bronchopulmonary dysplasia (BPD), which required proper treatment.https://www.gynecology.su/jour/article/view/2114post-term pregnancyporactant alphasurfactant-bltauractantacute neonatal distress syndromepersistent pulmonary hypertension of newbornshigh frequency oscillatory ventilation |
| spellingShingle | A. V. Mostovoi A. L. Karpova I. V. Popov L. A. Anikeeva N. Yu. Karpov Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report Акушерство, гинекология и репродукция post-term pregnancy poractant alpha surfactant-bl tauractant acute neonatal distress syndrome persistent pulmonary hypertension of newborns high frequency oscillatory ventilation |
| title | Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report |
| title_full | Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report |
| title_fullStr | Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report |
| title_full_unstemmed | Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report |
| title_short | Surfactant lung lavage in neonatal meconium aspiration syndrome as a life-saving respiratory strategy: literature review and a case report |
| title_sort | surfactant lung lavage in neonatal meconium aspiration syndrome as a life saving respiratory strategy literature review and a case report |
| topic | post-term pregnancy poractant alpha surfactant-bl tauractant acute neonatal distress syndrome persistent pulmonary hypertension of newborns high frequency oscillatory ventilation |
| url | https://www.gynecology.su/jour/article/view/2114 |
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