Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report
Complete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB. Cardiac magnetic resonance imaging revealed no signs of inflammation or other a...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-04-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0412 |
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| author | Zuoyi Zhou Long Zhang Qinhui Sheng Yanjun Gong Jianping Li |
| author_facet | Zuoyi Zhou Long Zhang Qinhui Sheng Yanjun Gong Jianping Li |
| author_sort | Zuoyi Zhou |
| collection | DOAJ |
| description | Complete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB. Cardiac magnetic resonance imaging revealed no signs of inflammation or other abnormalities. Whole-exome sequencing identified several variants, but none alone could explain the heart block. We hypothesize that AVB may be a potential complication of Alport syndrome or the result of multiple variants. A permanent pacemaker was implanted, and a 6-month follow-up confirmed the irreversibility of the AVB. |
| format | Article |
| id | doaj-art-a13cbf2c51134c0d9a2ccbd2695b160d |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-a13cbf2c51134c0d9a2ccbd2695b160d2025-08-20T03:08:40ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-04-014410.7326/aimcc.2024.0412Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case ReportZuoyi Zhou0Long Zhang1Qinhui Sheng2Yanjun Gong3Jianping Li41Department of Cardiology, Peking University First Hospital, Beijing, China1Department of Cardiology, Peking University First Hospital, Beijing, China1Department of Cardiology, Peking University First Hospital, Beijing, China1Department of Cardiology, Peking University First Hospital, Beijing, China1Department of Cardiology, Peking University First Hospital, Beijing, ChinaComplete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB. Cardiac magnetic resonance imaging revealed no signs of inflammation or other abnormalities. Whole-exome sequencing identified several variants, but none alone could explain the heart block. We hypothesize that AVB may be a potential complication of Alport syndrome or the result of multiple variants. A permanent pacemaker was implanted, and a 6-month follow-up confirmed the irreversibility of the AVB.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0412 |
| spellingShingle | Zuoyi Zhou Long Zhang Qinhui Sheng Yanjun Gong Jianping Li Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report |
| title_full | Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report |
| title_fullStr | Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report |
| title_full_unstemmed | Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report |
| title_short | Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report |
| title_sort | complete atrioventricular block in a young patient with alport syndrome a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0412 |
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