Complete Atrioventricular Block in a Young Patient With Alport Syndrome: A Case Report
Complete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB. Cardiac magnetic resonance imaging revealed no signs of inflammation or other a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2025-04-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0412 |
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| Summary: | Complete atrioventricular block (AVB) has not been previously reported in patients with Alport syndrome with normal kidney function. We describe a rare case of a young man with Alport syndrome who developed complete AVB. Cardiac magnetic resonance imaging revealed no signs of inflammation or other abnormalities. Whole-exome sequencing identified several variants, but none alone could explain the heart block. We hypothesize that AVB may be a potential complication of Alport syndrome or the result of multiple variants. A permanent pacemaker was implanted, and a 6-month follow-up confirmed the irreversibility of the AVB. |
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| ISSN: | 2767-7664 |