Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
Objectives Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-02-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/2/e063141.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849705554797133824 |
|---|---|
| author | Kye E Poronsky Katherine E Fleming-Dutra Nicholas M Mohr Peter C Hou Elizabeth Krebs Sharon H Saydah Wei Xing Anusha Krishnadasan Eva González David A Talan Gregory J Moran Karin F Hoth Shannon Landers Ian D Plumb Kari K Harland Tamara Pilishvili Zachary Mankoff John P Haran Melissa Briggs-Hagen Eliezer Santos León Howard A Smithline Lilly C Lee Stephen C Lim Mark T Steele David G Beiser Brett Faine Utsav Nandi Walter A Schrading Brian Chinnock Anne Chipman Megan Fuentes Frank LoVecchio Bradley Clinansmith Alysia Horcher Kelli Wallace Lisandra Uribe Kavitha Pathmarajah Dean M Hashimoto Monica Bahamon Michelle St Romain Efrat Kean Amy Stubbs Sara Roy Gregory Volturo Amanda Higgins James Galbraith James C Crosby Mary Mulrow Ryan Gierke Jennifer L Farrar Yunmi Chung Anna Yousaf Jennifer Onukwube Okaro Glen R Abedi Sankan Nyanseor Christopher K Watts |
| author_facet | Kye E Poronsky Katherine E Fleming-Dutra Nicholas M Mohr Peter C Hou Elizabeth Krebs Sharon H Saydah Wei Xing Anusha Krishnadasan Eva González David A Talan Gregory J Moran Karin F Hoth Shannon Landers Ian D Plumb Kari K Harland Tamara Pilishvili Zachary Mankoff John P Haran Melissa Briggs-Hagen Eliezer Santos León Howard A Smithline Lilly C Lee Stephen C Lim Mark T Steele David G Beiser Brett Faine Utsav Nandi Walter A Schrading Brian Chinnock Anne Chipman Megan Fuentes Frank LoVecchio Bradley Clinansmith Alysia Horcher Kelli Wallace Lisandra Uribe Kavitha Pathmarajah Dean M Hashimoto Monica Bahamon Michelle St Romain Efrat Kean Amy Stubbs Sara Roy Gregory Volturo Amanda Higgins James Galbraith James C Crosby Mary Mulrow Ryan Gierke Jennifer L Farrar Yunmi Chung Anna Yousaf Jennifer Onukwube Okaro Glen R Abedi Sankan Nyanseor Christopher K Watts |
| author_sort | Kye E Poronsky |
| collection | DOAJ |
| description | Objectives Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work.Design Cohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset.Setting Health systems in 12 US states.Participants HCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset.Exposures Two doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine.Main outcome measures Prevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work.Results Among 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79).Conclusions Receipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work. |
| format | Article |
| id | doaj-art-a13b12e1429245aaa52c10d26627a72c |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-a13b12e1429245aaa52c10d26627a72c2025-08-20T03:16:26ZengBMJ Publishing GroupBMJ Open2044-60552023-02-0113210.1136/bmjopen-2022-063141Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort studyKye E PoronskyKatherine E Fleming-Dutra0Nicholas M Mohr1Peter C HouElizabeth KrebsSharon H Saydah2Wei XingAnusha Krishnadasan3Eva González4David A Talan5Gregory J MoranKarin F Hoth6Shannon LandersIan D Plumb7Kari K Harland8Tamara Pilishvili9Zachary Mankoff10John P Haran11Melissa Briggs-Hagen12Eliezer Santos León13Howard A SmithlineLilly C LeeStephen C LimMark T SteeleDavid G BeiserBrett FaineUtsav NandiWalter A SchradingBrian ChinnockAnne ChipmanMegan FuentesFrank LoVecchioBradley ClinansmithAlysia HorcherKelli WallaceLisandra UribeKavitha PathmarajahDean M HashimotoMonica BahamonMichelle St RomainEfrat KeanAmy StubbsSara RoyGregory VolturoAmanda Higgins14James GalbraithJames C CrosbyMary MulrowRyan GierkeJennifer L FarrarYunmi ChungAnna YousafJennifer Onukwube OkaroGlen R AbediSankan NyanseorChristopher K WattsCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAAnesthesia, University of Iowa Carver College of Medicine, Iowa City, Iowa, USACOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAOlive View and Ronald Reagan-UCLA Medical Center Emergency Medicine, University of California - Los Angeles, Los Angeles, California, USAInterventional Neuroradiology, Hospital Universitario Cruces, Barakaldo, SpainOlive View and Ronald Reagan-UCLA Medical Center Emergency Medicine, University of California - Los Angeles, Los Angeles, California, USAInternal Medicine, University of Iowa Carver College of Medicine, Iowa CIty, Iowa, USACOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAEmergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USACOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAEmergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USAEmergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USANational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USAEmergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USA9 Integrated Knowledge Translation Panel Member, Toronto, Ontario, CanadaObjectives Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work.Design Cohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset.Setting Health systems in 12 US states.Participants HCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset.Exposures Two doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine.Main outcome measures Prevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work.Results Among 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79).Conclusions Receipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work.https://bmjopen.bmj.com/content/13/2/e063141.full |
| spellingShingle | Kye E Poronsky Katherine E Fleming-Dutra Nicholas M Mohr Peter C Hou Elizabeth Krebs Sharon H Saydah Wei Xing Anusha Krishnadasan Eva González David A Talan Gregory J Moran Karin F Hoth Shannon Landers Ian D Plumb Kari K Harland Tamara Pilishvili Zachary Mankoff John P Haran Melissa Briggs-Hagen Eliezer Santos León Howard A Smithline Lilly C Lee Stephen C Lim Mark T Steele David G Beiser Brett Faine Utsav Nandi Walter A Schrading Brian Chinnock Anne Chipman Megan Fuentes Frank LoVecchio Bradley Clinansmith Alysia Horcher Kelli Wallace Lisandra Uribe Kavitha Pathmarajah Dean M Hashimoto Monica Bahamon Michelle St Romain Efrat Kean Amy Stubbs Sara Roy Gregory Volturo Amanda Higgins James Galbraith James C Crosby Mary Mulrow Ryan Gierke Jennifer L Farrar Yunmi Chung Anna Yousaf Jennifer Onukwube Okaro Glen R Abedi Sankan Nyanseor Christopher K Watts Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study BMJ Open |
| title | Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study |
| title_full | Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study |
| title_fullStr | Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study |
| title_full_unstemmed | Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study |
| title_short | Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study |
| title_sort | presence of symptoms 6 weeks after covid 19 among vaccinated and unvaccinated us healthcare personnel a prospective cohort study |
| url | https://bmjopen.bmj.com/content/13/2/e063141.full |
| work_keys_str_mv | AT kyeeporonsky presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT katherineeflemingdutra presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT nicholasmmohr presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT peterchou presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT elizabethkrebs presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT sharonhsaydah presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT weixing presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT anushakrishnadasan presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT evagonzalez presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT davidatalan presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT gregoryjmoran presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT karinfhoth presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT shannonlanders presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT iandplumb presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT karikharland presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT tamarapilishvili presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT zacharymankoff presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT johnpharan presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT melissabriggshagen presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT eliezersantosleon presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT howardasmithline presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT lillyclee presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT stephenclim presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT marktsteele presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT davidgbeiser presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT brettfaine presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT utsavnandi presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT walteraschrading presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT brianchinnock presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT annechipman presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT meganfuentes presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT franklovecchio presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT bradleyclinansmith presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT alysiahorcher presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT kelliwallace presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT lisandrauribe presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT kavithapathmarajah presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT deanmhashimoto presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT monicabahamon presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT michellestromain presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT efratkean presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT amystubbs presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT sararoy presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT gregoryvolturo presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT amandahiggins presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT jamesgalbraith presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT jamesccrosby presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT marymulrow presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT ryangierke presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT jenniferlfarrar presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT yunmichung presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT annayousaf presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT jenniferonukwubeokaro presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT glenrabedi presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT sankannyanseor presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy AT christopherkwatts presenceofsymptoms6weeksaftercovid19amongvaccinatedandunvaccinatedushealthcarepersonnelaprospectivecohortstudy |