Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia
Abstract Background Fibromyalgia (FM) is a musculoskeletal syndrome characterized by diffuse and chronic pain associated with other symptoms such as fatigue, sleep/cognition disorders, headache, depression and anxiety, resulting from a change in pain processing. Previous research has shown an increa...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-025-00453-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849738367352176640 |
|---|---|
| author | Carolina Dias da Silva Amorim Marco Felipe Macêdo Alves Marcella Dias Teixeira Larissa Vasconcelos Queiroz Thaysa Walleria de Aragão Santos Aline Ranzolin Danyelly Bruneska Gondin Martins Claudia Diniz Lopes Marques |
| author_facet | Carolina Dias da Silva Amorim Marco Felipe Macêdo Alves Marcella Dias Teixeira Larissa Vasconcelos Queiroz Thaysa Walleria de Aragão Santos Aline Ranzolin Danyelly Bruneska Gondin Martins Claudia Diniz Lopes Marques |
| author_sort | Carolina Dias da Silva Amorim |
| collection | DOAJ |
| description | Abstract Background Fibromyalgia (FM) is a musculoskeletal syndrome characterized by diffuse and chronic pain associated with other symptoms such as fatigue, sleep/cognition disorders, headache, depression and anxiety, resulting from a change in pain processing. Previous research has shown an increase in some interleukins (IL) in patients with FM when compared to controls, however, there is still no uniformity and consensus in the results. There is no study that evaluates IL8 mRNA expression in FM and its association with obesity and other clinical parameters. This study aims to verify the impact of IL8 mRNA expression on the clinical parameters of patients with FM (FMG) in relation to the comparison group (CG). Method This study evaluated patients diagnosed with FM treated at the rheumatology service of the Hospital das Clínicas of the Federal University of Pernambuco (HC-UFPE). The CG group was composed of individuals without chronic pain (companions of the patients and hospital employees). Clinical and demographic data were collected in both groups, and questionnaires for fatigue (FACIT-F), impact of FM (FIQ-R), depression (BDI), and sleep (NRS) were applied to both groups. Peripheral blood was collected for evaluation of IL8 gene expression through real time polymerase chain reaction (qPCR). Results Patients with FM show a lower frequency of IL8 gene expression compared to the CG, but FMG presented mainly up regulated in relation to CG. There was no association of IL8 expression and worse FIQ-R indices, sleep disturbance, BMI or fatigue. However, there was an association between IL8 expression and moderate depression (p = 0.002) and physical activity (p = 0.039), where patients in FMG who did express IL8 were practicing less physical activity. Conclusion Patients in FMG did not have a higher frequency of IL8 expression compared to CG, however patients with IL8 expression have a greater association with moderate depression. |
| format | Article |
| id | doaj-art-a13a1c6dca074769b7624488ffada463 |
| institution | DOAJ |
| issn | 2523-3106 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj-art-a13a1c6dca074769b7624488ffada4632025-08-20T03:06:36ZengBMCAdvances in Rheumatology2523-31062025-04-0165111010.1186/s42358-025-00453-8Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgiaCarolina Dias da Silva Amorim0Marco Felipe Macêdo Alves1Marcella Dias Teixeira2Larissa Vasconcelos Queiroz3Thaysa Walleria de Aragão Santos4Aline Ranzolin5Danyelly Bruneska Gondin Martins6Claudia Diniz Lopes Marques7Programa de pós-graduação em Saúde Translacional, Centro de Ciências Médicas, Universidade Federal de PernambucoPrograma de residência médica em reumatologia do Hospital das Clínicas/Ebserh, Universidade Federal de PernambucoPrograma de residência médica em reumatologia do Hospital das Clínicas/Ebserh, Universidade Federal de PernambucoPrograma de residência médica em reumatologia do Hospital das Clínicas/Ebserh, Universidade Federal de PernambucoInstituto Keizo Asami (iLIKA), Centro de Biociências, Universidade Federal de PernambucoHospital das Clínicas, Universidade Federal de Pernambuco, Empresa Brasileira de Serviços Hospitalares (Ebserh)Instituto Keizo Asami (iLIKA), Centro de Biociências, Universidade Federal de PernambucoHospital das Clínicas, Universidade Federal de Pernambuco, Empresa Brasileira de Serviços Hospitalares (Ebserh)Abstract Background Fibromyalgia (FM) is a musculoskeletal syndrome characterized by diffuse and chronic pain associated with other symptoms such as fatigue, sleep/cognition disorders, headache, depression and anxiety, resulting from a change in pain processing. Previous research has shown an increase in some interleukins (IL) in patients with FM when compared to controls, however, there is still no uniformity and consensus in the results. There is no study that evaluates IL8 mRNA expression in FM and its association with obesity and other clinical parameters. This study aims to verify the impact of IL8 mRNA expression on the clinical parameters of patients with FM (FMG) in relation to the comparison group (CG). Method This study evaluated patients diagnosed with FM treated at the rheumatology service of the Hospital das Clínicas of the Federal University of Pernambuco (HC-UFPE). The CG group was composed of individuals without chronic pain (companions of the patients and hospital employees). Clinical and demographic data were collected in both groups, and questionnaires for fatigue (FACIT-F), impact of FM (FIQ-R), depression (BDI), and sleep (NRS) were applied to both groups. Peripheral blood was collected for evaluation of IL8 gene expression through real time polymerase chain reaction (qPCR). Results Patients with FM show a lower frequency of IL8 gene expression compared to the CG, but FMG presented mainly up regulated in relation to CG. There was no association of IL8 expression and worse FIQ-R indices, sleep disturbance, BMI or fatigue. However, there was an association between IL8 expression and moderate depression (p = 0.002) and physical activity (p = 0.039), where patients in FMG who did express IL8 were practicing less physical activity. Conclusion Patients in FMG did not have a higher frequency of IL8 expression compared to CG, however patients with IL8 expression have a greater association with moderate depression.https://doi.org/10.1186/s42358-025-00453-8FibromyalgiaInterleukin 8DepressionFatigueSleep qualityObesity |
| spellingShingle | Carolina Dias da Silva Amorim Marco Felipe Macêdo Alves Marcella Dias Teixeira Larissa Vasconcelos Queiroz Thaysa Walleria de Aragão Santos Aline Ranzolin Danyelly Bruneska Gondin Martins Claudia Diniz Lopes Marques Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia Advances in Rheumatology Fibromyalgia Interleukin 8 Depression Fatigue Sleep quality Obesity |
| title | Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia |
| title_full | Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia |
| title_fullStr | Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia |
| title_full_unstemmed | Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia |
| title_short | Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia |
| title_sort | evaluation of clinical impact of interleukin 8 gene expression in patients with fibromyalgia |
| topic | Fibromyalgia Interleukin 8 Depression Fatigue Sleep quality Obesity |
| url | https://doi.org/10.1186/s42358-025-00453-8 |
| work_keys_str_mv | AT carolinadiasdasilvaamorim evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT marcofelipemacedoalves evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT marcelladiasteixeira evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT larissavasconcelosqueiroz evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT thaysawalleriadearagaosantos evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT alineranzolin evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT danyellybruneskagondinmartins evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia AT claudiadinizlopesmarques evaluationofclinicalimpactofinterleukin8geneexpressioninpatientswithfibromyalgia |