Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis
Introduction: We aimed to systematically evaluate the most recent evidence regarding the potential short-term and long-term synergistic effects of transcranial direct-current stimulation (tDCS) and cognitive training (CT) on the memory of individuals with mild cognitive impairment (MCI) or dementia...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-11-01
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| Series: | Journal of Modern Rehabilitation |
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| Online Access: | https://jmr.tums.ac.ir/index.php/jmr/article/view/1055 |
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| _version_ | 1823863937708326912 |
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| author | Ka Yin Chu King Hei King Cheng |
| author_facet | Ka Yin Chu King Hei King Cheng |
| author_sort | Ka Yin Chu |
| collection | DOAJ |
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Introduction: We aimed to systematically evaluate the most recent evidence regarding the potential short-term and long-term synergistic effects of transcranial direct-current stimulation (tDCS) and cognitive training (CT) on the memory of individuals with mild cognitive impairment (MCI) or dementia and to explore the optimal treatment protocol.
Materials and Methods: Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a comprehensive literature search on PubMed, Medline, CINAHL and EMBASE was conducted to identify eligible randomized controlled trials (RCTs) published up to December 2022. The identified studies were summarized and analyzed to examine the efficacy of the combined intervention.
Results: Ten studies involving participants with MCI or dementia were included. Four RCTs with memory-related outcomes were analyzed. A small-to-medium effect size (ES) of 0.28 was found for the short-term effect (95% CI, 0.02%, 0.55%). However, the long-term effect was non-significant, with an ES of 0.17 (95% CI, -0.09%, 0.44%).
Conclusion: The combined intervention appears to effectively mitigate cognitive decline in the short term only. Optimal treatment protocol remains inconclusive due to heterogeneity among studies. More robust evidence is required to determine whether the combined approach can serve as an effective intervention in clinical practice.
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| format | Article |
| id | doaj-art-a1367f8353ef4819b4adac42bfc8070d |
| institution | Kabale University |
| issn | 2538-385X 2538-3868 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Modern Rehabilitation |
| spelling | doaj-art-a1367f8353ef4819b4adac42bfc8070d2025-02-09T09:07:30ZengTehran University of Medical SciencesJournal of Modern Rehabilitation2538-385X2538-38682024-11-0119110.18502/jmr.v19i1.17504Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-AnalysisKa Yin Chu0King Hei King Cheng1Department of Occupational Therapy, Wong Tai Sin Hospital, Hong Kong, China.Department of Occupational Therapy, Ruttonjee Hospital, Hong Kong, China. Introduction: We aimed to systematically evaluate the most recent evidence regarding the potential short-term and long-term synergistic effects of transcranial direct-current stimulation (tDCS) and cognitive training (CT) on the memory of individuals with mild cognitive impairment (MCI) or dementia and to explore the optimal treatment protocol. Materials and Methods: Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a comprehensive literature search on PubMed, Medline, CINAHL and EMBASE was conducted to identify eligible randomized controlled trials (RCTs) published up to December 2022. The identified studies were summarized and analyzed to examine the efficacy of the combined intervention. Results: Ten studies involving participants with MCI or dementia were included. Four RCTs with memory-related outcomes were analyzed. A small-to-medium effect size (ES) of 0.28 was found for the short-term effect (95% CI, 0.02%, 0.55%). However, the long-term effect was non-significant, with an ES of 0.17 (95% CI, -0.09%, 0.44%). Conclusion: The combined intervention appears to effectively mitigate cognitive decline in the short term only. Optimal treatment protocol remains inconclusive due to heterogeneity among studies. More robust evidence is required to determine whether the combined approach can serve as an effective intervention in clinical practice. https://jmr.tums.ac.ir/index.php/jmr/article/view/1055RehabilitationCognitive dysfunctionTranscranial direct-current stimulation Cognitive trainingNeuroscience |
| spellingShingle | Ka Yin Chu King Hei King Cheng Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis Journal of Modern Rehabilitation Rehabilitation Cognitive dysfunction Transcranial direct-current stimulation Cognitive training Neuroscience |
| title | Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis |
| title_full | Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis |
| title_fullStr | Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis |
| title_short | Effects of Transcranial Direct-Current Stimulation and Cognitive Training on Individuals with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis |
| title_sort | effects of transcranial direct current stimulation and cognitive training on individuals with mild cognitive impairment and dementia a systematic review and meta analysis |
| topic | Rehabilitation Cognitive dysfunction Transcranial direct-current stimulation Cognitive training Neuroscience |
| url | https://jmr.tums.ac.ir/index.php/jmr/article/view/1055 |
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