Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation

Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation

Osteoarthritis (OA) is a musculoskeletal degenerative disease characterized by alterations in cartilage and subchondral bone leading to impaired joint function. OA disproportionally affects females more than males, yet the molecular mechanisms underlying these biological sex differences remain elusi...

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Bibliographic Details
Main Authors: Francisco Conceição, João Meneses, Filipa Lebre, Malin Becker, Nuno Araújo-Gomes, Rianne Vos, Ana R. Ribeiro, Ernesto Alfaro-Moreno, Jeroen Leijten, Liliana Moreira Teixeira
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Organ-on-chip
Osteoarthritis
Sex differences
Metabolic labeling
Chondrocytes
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642500287X
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