Smart drug delivery and responsive microneedles for wound healing
Wound healing is an ongoing concern for the medical community. The limitations of traditional dressings are being addressed by materials and manufacturing technology. Microneedles (MNs) are a novel type of drug delivery system that has been widely used in cancer therapy, dermatological treatment, an...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642400382X |
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| author | Meixuan Liu Jing Jiang Yiran Wang Huan Liu Yiping Lu Xingang Wang |
| author_facet | Meixuan Liu Jing Jiang Yiran Wang Huan Liu Yiping Lu Xingang Wang |
| author_sort | Meixuan Liu |
| collection | DOAJ |
| description | Wound healing is an ongoing concern for the medical community. The limitations of traditional dressings are being addressed by materials and manufacturing technology. Microneedles (MNs) are a novel type of drug delivery system that has been widely used in cancer therapy, dermatological treatment, and insulin and vaccine delivery. MNs locally penetrate necrotic tissue, eschar, biofilm and epidermis into deep tissues, avoiding the possibility of drug dilution and degradation and greatly improving administration efficiency with less pain. MNs represent a new direction for wound treatment and transdermal delivery. In this study, we summarise the skin wound healing process and the mechanical stimulation of MNs in the context of the wound healing process. We also introduce the structural design and manufacture of MNs. Subsequently, MNs are categorised according to the loaded drugs, where the design of the MNs according to the traumatic biological/biochemical microenvironment (pH, glucose, and bacteria) and the physical microenvironment (temperature, light, and ultrasound) is emphasised. Finally, the advantages of MNs are compared with traditional drug delivery systems and their prospects are discussed. |
| format | Article |
| id | doaj-art-a133b32a1f964c5ab12fc2f56bed39cc |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-a133b32a1f964c5ab12fc2f56bed39cc2025-08-20T02:37:45ZengElsevierMaterials Today Bio2590-00642024-12-012910132110.1016/j.mtbio.2024.101321Smart drug delivery and responsive microneedles for wound healingMeixuan Liu0Jing Jiang1Yiran Wang2Huan Liu3Yiping Lu4Xingang Wang5Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaDepartment of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, ChinaSenior once Class 5, Shanghai Pinghe School, Shanghai, 200000, ChinaDepartment of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Corresponding author. Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.Wound healing is an ongoing concern for the medical community. The limitations of traditional dressings are being addressed by materials and manufacturing technology. Microneedles (MNs) are a novel type of drug delivery system that has been widely used in cancer therapy, dermatological treatment, and insulin and vaccine delivery. MNs locally penetrate necrotic tissue, eschar, biofilm and epidermis into deep tissues, avoiding the possibility of drug dilution and degradation and greatly improving administration efficiency with less pain. MNs represent a new direction for wound treatment and transdermal delivery. In this study, we summarise the skin wound healing process and the mechanical stimulation of MNs in the context of the wound healing process. We also introduce the structural design and manufacture of MNs. Subsequently, MNs are categorised according to the loaded drugs, where the design of the MNs according to the traumatic biological/biochemical microenvironment (pH, glucose, and bacteria) and the physical microenvironment (temperature, light, and ultrasound) is emphasised. Finally, the advantages of MNs are compared with traditional drug delivery systems and their prospects are discussed.http://www.sciencedirect.com/science/article/pii/S259000642400382XMicroneedlesWound healingDelivering drug systemSmart responsive microneedles |
| spellingShingle | Meixuan Liu Jing Jiang Yiran Wang Huan Liu Yiping Lu Xingang Wang Smart drug delivery and responsive microneedles for wound healing Materials Today Bio Microneedles Wound healing Delivering drug system Smart responsive microneedles |
| title | Smart drug delivery and responsive microneedles for wound healing |
| title_full | Smart drug delivery and responsive microneedles for wound healing |
| title_fullStr | Smart drug delivery and responsive microneedles for wound healing |
| title_full_unstemmed | Smart drug delivery and responsive microneedles for wound healing |
| title_short | Smart drug delivery and responsive microneedles for wound healing |
| title_sort | smart drug delivery and responsive microneedles for wound healing |
| topic | Microneedles Wound healing Delivering drug system Smart responsive microneedles |
| url | http://www.sciencedirect.com/science/article/pii/S259000642400382X |
| work_keys_str_mv | AT meixuanliu smartdrugdeliveryandresponsivemicroneedlesforwoundhealing AT jingjiang smartdrugdeliveryandresponsivemicroneedlesforwoundhealing AT yiranwang smartdrugdeliveryandresponsivemicroneedlesforwoundhealing AT huanliu smartdrugdeliveryandresponsivemicroneedlesforwoundhealing AT yipinglu smartdrugdeliveryandresponsivemicroneedlesforwoundhealing AT xingangwang smartdrugdeliveryandresponsivemicroneedlesforwoundhealing |