RIPK1 is required for ZBP1-driven necroptosis in human cells.

RIPK1 is required for ZBP1-driven necroptosis in human cells.

Necroptosis initiated by the host sensor Z-NA binding protein 1 (ZBP1) is essential for host defense against a growing number of viruses, including herpes simplex virus 1 (HSV-1). Studies with HSV-1 and other necroptogenic stimuli in murine settings have suggested that ZBP1 triggers necroptosis by d...

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Main Authors: Oluwamuyiwa T Amusan, Shuqi Wang, Chaoran Yin, Heather S Koehler, Yixun Li, Tencho Tenev, Rebecca Wilson, Benjamin Bellenie, Ting Zhang, Jian Wang, Chang Liu, Kim Seong, Seyedeh L Poorbaghi, Joseph Yates, Yuchen Shen, Jason W Upton, Pascal Meier, Siddharth Balachandran, Hongyan Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002845
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