Molecular Mechanisms of Cardioprotective Actions of Tanshinones
Tanshinones are lipophilic compounds derived from Salvia miltiorrhiza (Danshen) that has been widely used to treat coronary heart diseases in China. The cardioprotective actions of tanshinones have been extensively studied in various models of myocardial infarction, cardiac ischemia reperfusion inju...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/9150108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849398597450203136 |
|---|---|
| author | Hyou-Ju Jin Chun-Guang Li |
| author_facet | Hyou-Ju Jin Chun-Guang Li |
| author_sort | Hyou-Ju Jin |
| collection | DOAJ |
| description | Tanshinones are lipophilic compounds derived from Salvia miltiorrhiza (Danshen) that has been widely used to treat coronary heart diseases in China. The cardioprotective actions of tanshinones have been extensively studied in various models of myocardial infarction, cardiac ischemia reperfusion injury, cardiac hypertrophy, atherosclerosis, hypoxia, and cardiomyopathy. This review outlines the recent development in understanding the molecular mechanisms and signaling pathways involved in the cardioprotective actions of tanshinones, in particular on mitochondrial apoptosis, calcium, nitric oxide, ROS, TNF-α, PKC, PI3K/Akt, IKK/NF-κB, and TGF-β1/Smad mechanisms, which highlights the potential of these compounds as therapeutic agents for treating cardiovascular diseases. |
| format | Article |
| id | doaj-art-a110bc5313f04b57930e6ccf032d367b |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-a110bc5313f04b57930e6ccf032d367b2025-08-20T03:38:34ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/91501089150108Molecular Mechanisms of Cardioprotective Actions of TanshinonesHyou-Ju Jin0Chun-Guang Li1National Institute of Complementary Medicine, Western Sydney University, Penrith, NSW 2751, AustraliaNational Institute of Complementary Medicine, Western Sydney University, Penrith, NSW 2751, AustraliaTanshinones are lipophilic compounds derived from Salvia miltiorrhiza (Danshen) that has been widely used to treat coronary heart diseases in China. The cardioprotective actions of tanshinones have been extensively studied in various models of myocardial infarction, cardiac ischemia reperfusion injury, cardiac hypertrophy, atherosclerosis, hypoxia, and cardiomyopathy. This review outlines the recent development in understanding the molecular mechanisms and signaling pathways involved in the cardioprotective actions of tanshinones, in particular on mitochondrial apoptosis, calcium, nitric oxide, ROS, TNF-α, PKC, PI3K/Akt, IKK/NF-κB, and TGF-β1/Smad mechanisms, which highlights the potential of these compounds as therapeutic agents for treating cardiovascular diseases.http://dx.doi.org/10.1155/2016/9150108 |
| spellingShingle | Hyou-Ju Jin Chun-Guang Li Molecular Mechanisms of Cardioprotective Actions of Tanshinones Journal of Chemistry |
| title | Molecular Mechanisms of Cardioprotective Actions of Tanshinones |
| title_full | Molecular Mechanisms of Cardioprotective Actions of Tanshinones |
| title_fullStr | Molecular Mechanisms of Cardioprotective Actions of Tanshinones |
| title_full_unstemmed | Molecular Mechanisms of Cardioprotective Actions of Tanshinones |
| title_short | Molecular Mechanisms of Cardioprotective Actions of Tanshinones |
| title_sort | molecular mechanisms of cardioprotective actions of tanshinones |
| url | http://dx.doi.org/10.1155/2016/9150108 |
| work_keys_str_mv | AT hyoujujin molecularmechanismsofcardioprotectiveactionsoftanshinones AT chunguangli molecularmechanismsofcardioprotectiveactionsoftanshinones |