Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress

Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress

IntroductionOrthodontic tooth movement (OTM) and treatment-associated pain are closely related processes driven by a local inflammatory response modulated by periodontal ligament fibroblasts (PdLFs). Increased levels of substance P (SP), a well-characterized tachykinin, has been demonstrated in the...

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Bibliographic Details
Main Authors: Judit Symmank, Lara Löffler, Ulrike Schulze-Späte, Collin Jacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
nociception
orthodontics
periodontal ligament fibroblasts
substance P
TAC1
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1583908/full
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