The dynamics of CD4+ T cell proliferation and regulation
We use mathematical modeling to study the proliferation dynamics of CD4+ T cells within an immune response. This proliferation is driven by the autocrine reaction of helper T cells and interleukin-2 (IL-2), and regulated by natural regulatory T cells (nTregs). Previous studies suggested that a fratr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Biological Dynamics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17513758.2025.2458867 |
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| author | Mingran Zhang Junling Ma Roderick Edwards Meili Li |
| author_facet | Mingran Zhang Junling Ma Roderick Edwards Meili Li |
| author_sort | Mingran Zhang |
| collection | DOAJ |
| description | We use mathematical modeling to study the proliferation dynamics of CD4+ T cells within an immune response. This proliferation is driven by the autocrine reaction of helper T cells and interleukin-2 (IL-2), and regulated by natural regulatory T cells (nTregs). Previous studies suggested that a fratricidal mechanism is necessary to eliminate helper T cells post-infection. Contrary to this, our mathematical analysis establishes that the depletion of these cells is due to two pivotal factors: the saturation in the proliferation rate of helper CD4+ T cells at high IL-2 concentrations, and the activation rate of nTregs outpacing their death rate. This yields an excitable process, such that the proliferation starts once the helper T cell population passes a threshold. Additionally, we find that when the proliferation of nTregs lags behind their mortality, induced regulatory T cells (iTregs) are crucial to curbing the proliferation of helper CD4+ T cells. |
| format | Article |
| id | doaj-art-a10fdd28f20a479f962988ae4c22cc56 |
| institution | Kabale University |
| issn | 1751-3758 1751-3766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Biological Dynamics |
| spelling | doaj-art-a10fdd28f20a479f962988ae4c22cc562025-01-30T07:00:31ZengTaylor & Francis GroupJournal of Biological Dynamics1751-37581751-37662025-12-0119110.1080/17513758.2025.2458867The dynamics of CD4+ T cell proliferation and regulationMingran Zhang0Junling Ma1Roderick Edwards2Meili Li3College of Information Science and Technology, Donghua University, Shanghai, People’s Republic of ChinaDepartment of Mathematics and Statistics, University of Victoria, Victoria, BC, CanadaDepartment of Mathematics and Statistics, University of Victoria, Victoria, BC, CanadaSchool of Mathematics and Statistics, Donghua University, Shanghai, People’s Republic of ChinaWe use mathematical modeling to study the proliferation dynamics of CD4+ T cells within an immune response. This proliferation is driven by the autocrine reaction of helper T cells and interleukin-2 (IL-2), and regulated by natural regulatory T cells (nTregs). Previous studies suggested that a fratricidal mechanism is necessary to eliminate helper T cells post-infection. Contrary to this, our mathematical analysis establishes that the depletion of these cells is due to two pivotal factors: the saturation in the proliferation rate of helper CD4+ T cells at high IL-2 concentrations, and the activation rate of nTregs outpacing their death rate. This yields an excitable process, such that the proliferation starts once the helper T cell population passes a threshold. Additionally, we find that when the proliferation of nTregs lags behind their mortality, induced regulatory T cells (iTregs) are crucial to curbing the proliferation of helper CD4+ T cells.https://www.tandfonline.com/doi/10.1080/17513758.2025.2458867Proliferation dynamicsnTregsiTregsinterleukin-2ODE model92C30 |
| spellingShingle | Mingran Zhang Junling Ma Roderick Edwards Meili Li The dynamics of CD4+ T cell proliferation and regulation Journal of Biological Dynamics Proliferation dynamics nTregs iTregs interleukin-2 ODE model 92C30 |
| title | The dynamics of CD4+ T cell proliferation and regulation |
| title_full | The dynamics of CD4+ T cell proliferation and regulation |
| title_fullStr | The dynamics of CD4+ T cell proliferation and regulation |
| title_full_unstemmed | The dynamics of CD4+ T cell proliferation and regulation |
| title_short | The dynamics of CD4+ T cell proliferation and regulation |
| title_sort | dynamics of cd4 t cell proliferation and regulation |
| topic | Proliferation dynamics nTregs iTregs interleukin-2 ODE model 92C30 |
| url | https://www.tandfonline.com/doi/10.1080/17513758.2025.2458867 |
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