Bile acids affect intestinal barrier function through FXR and TGR5

Bile acids affect intestinal barrier function through FXR and TGR5

Bile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, making bile acid metabolism a critical regulator of intestina...

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Bibliographic Details
Main Authors: Guangyao Song, Yuxiao Xie, Lanlan Yi, Wenjie Cheng, Huijin Jia, Wenzhe Shi, Qiwei Liu, Ligui Fang, Shiqi Xue, Dan Liu, Junhong Zhu, Sumei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
bile acids
bile acid receptors
FXR
TGR5
intestinal barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1607899/full
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