The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland
Background. Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA). Objectives. To assess bone and cartilage serum biomarkers in psorias...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/194535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563650699722752 |
|---|---|
| author | Joanna Bartosińska Anna Michalak-Stoma Maria Juszkiewicz-Borowiec Małgorzata Kowal Grażyna Chodorowska |
| author_facet | Joanna Bartosińska Anna Michalak-Stoma Maria Juszkiewicz-Borowiec Małgorzata Kowal Grażyna Chodorowska |
| author_sort | Joanna Bartosińska |
| collection | DOAJ |
| description | Background. Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA). Objectives. To assess bone and cartilage serum biomarkers in psoriasis. Methods. The study was conducted in 2014 and included 61 psoriatic patients and 30 healthy individuals. In both groups, the serum concentrations of soluble receptor activator of nuclear factor-κB ligand (sRANKL), cartilage oligomeric matrix protein (COMP), osteoprotegerin (OPG), and interleukin-20 (IL-20) were examined. Severity of skin lesions was assessed by Psoriasis Area and Severity Index (PASI), body surface area (BSA), and Physician Global Assessment (PGA) scores. Results. The duration of psoriasis was from 1 year to 45 years. 22 patients suffered from concomitant PsA. The mean value of PASI was 23.1 ± 12.0 and BSA was 27.6 ± 20.6%. COMP, OPG, and IL-20 concentrations in psoriatic patients were significantly higher than in the control group. OPG/sRANKL ratio was significantly lower in PsA patients than in psoriatic patients without arthritis. Conclusions. Results of the conducted study suggest that COMP, OPG, IL-20, and OPG/sRANKL ratio may appear useful biomarkers of bone and cartilage involvement in psoriasis. |
| format | Article |
| id | doaj-art-a104e887745f42a6ba9bc748b357c1ce |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a104e887745f42a6ba9bc748b357c1ce2025-02-03T01:12:59ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/194535194535The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from PolandJoanna Bartosińska0Anna Michalak-Stoma1Maria Juszkiewicz-Borowiec2Małgorzata Kowal3Grażyna Chodorowska4Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, PolandDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, PolandDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, PolandDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, PolandDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, 13 Radziwillowska Street, 20-080 Lublin, PolandBackground. Psoriasis is an inflammatory disease in which joints involvement may be insidious and difficult to detect. Bone and cartilage biomarkers may be helpful in screening patients with psoriasis for psoriatic arthritis (PsA). Objectives. To assess bone and cartilage serum biomarkers in psoriasis. Methods. The study was conducted in 2014 and included 61 psoriatic patients and 30 healthy individuals. In both groups, the serum concentrations of soluble receptor activator of nuclear factor-κB ligand (sRANKL), cartilage oligomeric matrix protein (COMP), osteoprotegerin (OPG), and interleukin-20 (IL-20) were examined. Severity of skin lesions was assessed by Psoriasis Area and Severity Index (PASI), body surface area (BSA), and Physician Global Assessment (PGA) scores. Results. The duration of psoriasis was from 1 year to 45 years. 22 patients suffered from concomitant PsA. The mean value of PASI was 23.1 ± 12.0 and BSA was 27.6 ± 20.6%. COMP, OPG, and IL-20 concentrations in psoriatic patients were significantly higher than in the control group. OPG/sRANKL ratio was significantly lower in PsA patients than in psoriatic patients without arthritis. Conclusions. Results of the conducted study suggest that COMP, OPG, IL-20, and OPG/sRANKL ratio may appear useful biomarkers of bone and cartilage involvement in psoriasis.http://dx.doi.org/10.1155/2015/194535 |
| spellingShingle | Joanna Bartosińska Anna Michalak-Stoma Maria Juszkiewicz-Borowiec Małgorzata Kowal Grażyna Chodorowska The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland Mediators of Inflammation |
| title | The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland |
| title_full | The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland |
| title_fullStr | The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland |
| title_full_unstemmed | The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland |
| title_short | The Assessment of Selected Bone and Cartilage Biomarkers in Psoriatic Patients from Poland |
| title_sort | assessment of selected bone and cartilage biomarkers in psoriatic patients from poland |
| url | http://dx.doi.org/10.1155/2015/194535 |
| work_keys_str_mv | AT joannabartosinska theassessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT annamichalakstoma theassessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT mariajuszkiewiczborowiec theassessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT małgorzatakowal theassessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT grazynachodorowska theassessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT joannabartosinska assessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT annamichalakstoma assessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT mariajuszkiewiczborowiec assessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT małgorzatakowal assessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland AT grazynachodorowska assessmentofselectedboneandcartilagebiomarkersinpsoriaticpatientsfrompoland |