Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Abstract Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects. This study found that PDE increased histone 3 lysine 27 acety...

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Bibliographic Details
Main Authors: Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
adrenal steroid synthesis function impairment
bile acids
CYP27A1
prenatal dexamethasone exposure
therapeutic target
Online Access:https://doi.org/10.1002/advs.202413299
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https://doi.org/10.1002/advs.202413299

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