DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples

DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples

CYP3As are important drug-metabolizing enzymes in the liver. The causes for large inter-person variability in CYP3A expression/activity remain poorly understood. DNA methylation broadly regulates gene expression and the developmental transition from fetal CYP3A7 to adult CYP3A4, and CpG methylation...

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Bibliographic Details
Main Authors: Joseph M. Collins, Danxin Wang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
cytochrome P450s
CYP3A4
CYP3A5
CYP3A7
DNA methylation
gene expression
Online Access:https://www.mdpi.com/1420-3049/29/22/5407
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