Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential

Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential

Abstract Background Cell-free RNAs (cfRNAs) can be detected in biofluids and have emerged as valuable disease biomarkers. Accurate identification of the fragmented cfRNA signals, especially those originating from pathological cells, is crucial for understanding their biological functions and clinica...

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Main Authors: Pengfei Bao, Taiwei Wang, Xiaofan Liu, Shaozhen Xing, Hanjin Ruan, Hongli Ma, Yuhuan Tao, Qing Zhan, Efres Belmonte-Reche, Lizheng Qin, Zhengxue Han, Minghui Mao, Mengtao Li, Zhi John Lu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Subjects:
Cell-free RNA
CfRNA fragment
Peak calling
SncRNA
Liquid biopsy biomarker
Tissue-of-origin
Online Access:https://doi.org/10.1186/s13059-025-03590-x
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