Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies
Breast cancer is the most common type of cancer globally and presents an escalating problem and a huge burden on societies. Several strategies are implemented in clinics to treat patients and prevent disease incidence. Efforts to understand the underlying causes of disease emergence are pivotal, and...
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MDPI AG
2024-07-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/4/3/26 |
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| author | Mona Kamal Saadeldin Giuseppe Curigliano Amal Kamal Abdel-Aziz |
| author_facet | Mona Kamal Saadeldin Giuseppe Curigliano Amal Kamal Abdel-Aziz |
| author_sort | Mona Kamal Saadeldin |
| collection | DOAJ |
| description | Breast cancer is the most common type of cancer globally and presents an escalating problem and a huge burden on societies. Several strategies are implemented in clinics to treat patients and prevent disease incidence. Efforts to understand the underlying causes of disease emergence are pivotal, and the latest examination of human transcriptomic studies showed the involvement of the noncoding RNA regulatory molecules in influencing both pathological and physiological conditions. Several molecular mechanisms are involved in the process and collaborate to develop tumor plasticity and drug resistance. In this review, we highlight for the first time the interplay between long noncoding RNAs and Aurora kinases in breast cancer and review the latest advances in the field in an attempt to pave the way for a better understanding of the course of the disease and to delineate the targets for treatment strategies in the clinic. |
| format | Article |
| id | doaj-art-a0f54919eaec41fc80417e83322fdc1a |
| institution | OA Journals |
| issn | 2673-9879 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj-art-a0f54919eaec41fc80417e83322fdc1a2025-08-20T01:55:27ZengMDPI AGFuture Pharmacology2673-98792024-07-014346647810.3390/futurepharmacol4030026Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic StrategiesMona Kamal Saadeldin0Giuseppe Curigliano1Amal Kamal Abdel-Aziz2Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USAEuropean Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, ItalyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptBreast cancer is the most common type of cancer globally and presents an escalating problem and a huge burden on societies. Several strategies are implemented in clinics to treat patients and prevent disease incidence. Efforts to understand the underlying causes of disease emergence are pivotal, and the latest examination of human transcriptomic studies showed the involvement of the noncoding RNA regulatory molecules in influencing both pathological and physiological conditions. Several molecular mechanisms are involved in the process and collaborate to develop tumor plasticity and drug resistance. In this review, we highlight for the first time the interplay between long noncoding RNAs and Aurora kinases in breast cancer and review the latest advances in the field in an attempt to pave the way for a better understanding of the course of the disease and to delineate the targets for treatment strategies in the clinic.https://www.mdpi.com/2673-9879/4/3/26noncoding RNAsAurora AAurora BAurora Cbreast cancernovel strategies |
| spellingShingle | Mona Kamal Saadeldin Giuseppe Curigliano Amal Kamal Abdel-Aziz Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies Future Pharmacology noncoding RNAs Aurora A Aurora B Aurora C breast cancer novel strategies |
| title | Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies |
| title_full | Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies |
| title_fullStr | Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies |
| title_full_unstemmed | Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies |
| title_short | Deciphering the Complex Interplay of Long Noncoding RNAs and Aurora Kinases: Novel Insights into Breast Cancer Development and Therapeutic Strategies |
| title_sort | deciphering the complex interplay of long noncoding rnas and aurora kinases novel insights into breast cancer development and therapeutic strategies |
| topic | noncoding RNAs Aurora A Aurora B Aurora C breast cancer novel strategies |
| url | https://www.mdpi.com/2673-9879/4/3/26 |
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