Aspects of xenobiotics and their receptors in stroke
Abstract Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for ischemic stroke primarily aim to res...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
|
| Series: | Neuroprotection |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nep3.9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849430980944723968 |
|---|---|
| author | Aishika Datta Bijoyani Ghosh Deepaneeta Sarmah Antra Chaudhary Anupom Borah Pallab Bhattacharya |
| author_facet | Aishika Datta Bijoyani Ghosh Deepaneeta Sarmah Antra Chaudhary Anupom Borah Pallab Bhattacharya |
| author_sort | Aishika Datta |
| collection | DOAJ |
| description | Abstract Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for ischemic stroke primarily aim to restore cerebral blood flow by removing clots using intravenous thrombolysis and mechanical thrombectomy. However, hemorrhagic stroke requires different therapeutic interventions, where intravenous thrombolysis worsens the persistent condition. Nevertheless, the present treatment strategies do not provide effective neuroprotection as they have limitations such as narrow time window, specialized clinics and personnel, and higher expense. Therefore, studies on novel therapeutic strategies that can render neuroprotection over an extended time with minimum adverse effects are solicited. Xenobiotics are agents that are foreign to the biological system but can regulate their metabolism by binding to different xenobiotic receptors (XRs) to produce toxic substances. Modulation of XRs in different preclinical studies have shown benefits in the stroke outcome. Therefore, targeting XRs may be a future therapeutic strategy for stroke intervention. The present review briefly discusses various implications of xenobiotics and their receptors to evolve as a potential therapeutic target for prospective use as an adjunctive therapy for stroke. |
| format | Article |
| id | doaj-art-a0f46d3ef28c446cb9029eea48fc7976 |
| institution | Kabale University |
| issn | 2770-7296 2770-730X |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuroprotection |
| spelling | doaj-art-a0f46d3ef28c446cb9029eea48fc79762025-08-20T03:27:47ZengWileyNeuroprotection2770-72962770-730X2023-09-0111233410.1002/nep3.9Aspects of xenobiotics and their receptors in strokeAishika Datta0Bijoyani Ghosh1Deepaneeta Sarmah2Antra Chaudhary3Anupom Borah4Pallab Bhattacharya5Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat IndiaDepartment of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat IndiaDepartment of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat IndiaDepartment of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat IndiaDepartment of Life Science and Bioinformatics, Cellular and Molecular Neurobiology Laboratory Assam University Silchar Assam IndiaDepartment of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat IndiaAbstract Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic strategies for ischemic stroke primarily aim to restore cerebral blood flow by removing clots using intravenous thrombolysis and mechanical thrombectomy. However, hemorrhagic stroke requires different therapeutic interventions, where intravenous thrombolysis worsens the persistent condition. Nevertheless, the present treatment strategies do not provide effective neuroprotection as they have limitations such as narrow time window, specialized clinics and personnel, and higher expense. Therefore, studies on novel therapeutic strategies that can render neuroprotection over an extended time with minimum adverse effects are solicited. Xenobiotics are agents that are foreign to the biological system but can regulate their metabolism by binding to different xenobiotic receptors (XRs) to produce toxic substances. Modulation of XRs in different preclinical studies have shown benefits in the stroke outcome. Therefore, targeting XRs may be a future therapeutic strategy for stroke intervention. The present review briefly discusses various implications of xenobiotics and their receptors to evolve as a potential therapeutic target for prospective use as an adjunctive therapy for stroke.https://doi.org/10.1002/nep3.9biotransformationstrokexenobioticsxenosensors |
| spellingShingle | Aishika Datta Bijoyani Ghosh Deepaneeta Sarmah Antra Chaudhary Anupom Borah Pallab Bhattacharya Aspects of xenobiotics and their receptors in stroke Neuroprotection biotransformation stroke xenobiotics xenosensors |
| title | Aspects of xenobiotics and their receptors in stroke |
| title_full | Aspects of xenobiotics and their receptors in stroke |
| title_fullStr | Aspects of xenobiotics and their receptors in stroke |
| title_full_unstemmed | Aspects of xenobiotics and their receptors in stroke |
| title_short | Aspects of xenobiotics and their receptors in stroke |
| title_sort | aspects of xenobiotics and their receptors in stroke |
| topic | biotransformation stroke xenobiotics xenosensors |
| url | https://doi.org/10.1002/nep3.9 |
| work_keys_str_mv | AT aishikadatta aspectsofxenobioticsandtheirreceptorsinstroke AT bijoyanighosh aspectsofxenobioticsandtheirreceptorsinstroke AT deepaneetasarmah aspectsofxenobioticsandtheirreceptorsinstroke AT antrachaudhary aspectsofxenobioticsandtheirreceptorsinstroke AT anupomborah aspectsofxenobioticsandtheirreceptorsinstroke AT pallabbhattacharya aspectsofxenobioticsandtheirreceptorsinstroke |