COVID-19 and myotonic dystrophy: Case reports and systematic review
Introduction: Steinert's disease is a rare genetic disorder characterized by progressive myotonia and multi-organ damage. It is associated with respiratory and cardiological complications often leading patients to exitus. These conditions are also traditional risk factors for severe COVID-19....
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The Journal of Infection in Developing Countries
2023-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15653 |
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| author | Maria Mazzitelli Marco Trevenzoli Monica Brundu Giulia Squarzoni Anna Maria Cattelan |
| author_facet | Maria Mazzitelli Marco Trevenzoli Monica Brundu Giulia Squarzoni Anna Maria Cattelan |
| author_sort | Maria Mazzitelli |
| collection | DOAJ |
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Introduction: Steinert's disease is a rare genetic disorder characterized by progressive myotonia and multi-organ damage. It is associated with respiratory and cardiological complications often leading patients to exitus. These conditions are also traditional risk factors for severe COVID-19. SARS-CoV-2 has affected people with chronic diseases, but the impact on people with Steinert's disease is poorly defined, with only a few reported and described. More data are needed to understand whether this genetic disease is a risk factor for more serious evolution or death in patients with COVID-19.
Methodology: The study describes two cases of patients with SD and COVID-19 and summarizes available evidence of the clinical outcome of COVID-19 in patients with Steinert's disease, by performing a systematic review of the literature (following PRISMA statements and performing PROSPERO registration).
Results: Overall, 5 cases were retrieved from the literature review, with a median age of 47 years, of whom 4 had advanced SD and unfortunately died. By contrast, the 2 patients from our clinical practice and 1 from literature had a good clinical outcomes. Mortality ranged from 57% (all cases) to 80% (only literature review).
Conclusions: There is a high mortality rate in patients with both Steinert's disease and COVID-19. It highlights the importance of strengthening prevention strategies, especially vaccination. All SD with SARS-CoV-2 infection/COVID-19 patients should be identified early and treated to avoid complications. It is still unknown which treatment regimen is best to use in those patients. Studies on a greater number of patients are necessary to provide clinicians with further evidence.
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| format | Article |
| id | doaj-art-a0f27aa551974cd8ae0144cbbe829a94 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-a0f27aa551974cd8ae0144cbbe829a942025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-02-01170210.3855/jidc.15653COVID-19 and myotonic dystrophy: Case reports and systematic reviewMaria Mazzitelli0Marco Trevenzoli1Monica Brundu2Giulia Squarzoni3Anna Maria Cattelan4Infectious and Tropical Diseases Unit, Padua Hospital, Padua, ItalyInfectious and Tropical Diseases Unit, Padua Hospital, Padua, ItalyInfectious and Tropical Diseases Unit, Padua Hospital, Padua, ItalyRespiratory Disease Unit, Department of Cardiac Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, ItalyInfectious and Tropical Diseases Unit, Padua Hospital, Padua, Italy Introduction: Steinert's disease is a rare genetic disorder characterized by progressive myotonia and multi-organ damage. It is associated with respiratory and cardiological complications often leading patients to exitus. These conditions are also traditional risk factors for severe COVID-19. SARS-CoV-2 has affected people with chronic diseases, but the impact on people with Steinert's disease is poorly defined, with only a few reported and described. More data are needed to understand whether this genetic disease is a risk factor for more serious evolution or death in patients with COVID-19. Methodology: The study describes two cases of patients with SD and COVID-19 and summarizes available evidence of the clinical outcome of COVID-19 in patients with Steinert's disease, by performing a systematic review of the literature (following PRISMA statements and performing PROSPERO registration). Results: Overall, 5 cases were retrieved from the literature review, with a median age of 47 years, of whom 4 had advanced SD and unfortunately died. By contrast, the 2 patients from our clinical practice and 1 from literature had a good clinical outcomes. Mortality ranged from 57% (all cases) to 80% (only literature review). Conclusions: There is a high mortality rate in patients with both Steinert's disease and COVID-19. It highlights the importance of strengthening prevention strategies, especially vaccination. All SD with SARS-CoV-2 infection/COVID-19 patients should be identified early and treated to avoid complications. It is still unknown which treatment regimen is best to use in those patients. Studies on a greater number of patients are necessary to provide clinicians with further evidence. https://jidc.org/index.php/journal/article/view/15653COVID-19SARS-CoV-2Steinert’s diseasemyotonic dystrophyneurologic disorders |
| spellingShingle | Maria Mazzitelli Marco Trevenzoli Monica Brundu Giulia Squarzoni Anna Maria Cattelan COVID-19 and myotonic dystrophy: Case reports and systematic review Journal of Infection in Developing Countries COVID-19 SARS-CoV-2 Steinert’s disease myotonic dystrophy neurologic disorders |
| title | COVID-19 and myotonic dystrophy: Case reports and systematic review |
| title_full | COVID-19 and myotonic dystrophy: Case reports and systematic review |
| title_fullStr | COVID-19 and myotonic dystrophy: Case reports and systematic review |
| title_full_unstemmed | COVID-19 and myotonic dystrophy: Case reports and systematic review |
| title_short | COVID-19 and myotonic dystrophy: Case reports and systematic review |
| title_sort | covid 19 and myotonic dystrophy case reports and systematic review |
| topic | COVID-19 SARS-CoV-2 Steinert’s disease myotonic dystrophy neurologic disorders |
| url | https://jidc.org/index.php/journal/article/view/15653 |
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