High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles
Antiphospholipid antibodies (APAs) are developed antibodies to the phospholipid surfaces or to the proteins binding to phospholipids. Increased PS-expressed red blood cells (RBC) may be a risk factor in APAs development. There were only a few studies reported on APAs in thalassemia, and their associ...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2020-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/4286 |
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| author | Jitlada Chinsuwan Phatchanat Klaihmon Praguywan Kadegasem Ampaiwan Chuansumrit Anucha Soisamrong Kovit Pattanapanyasat Pakawan Wongwerawattanakoon Nongnuch Sirachainan |
| author_facet | Jitlada Chinsuwan Phatchanat Klaihmon Praguywan Kadegasem Ampaiwan Chuansumrit Anucha Soisamrong Kovit Pattanapanyasat Pakawan Wongwerawattanakoon Nongnuch Sirachainan |
| author_sort | Jitlada Chinsuwan |
| collection | DOAJ |
| description | Antiphospholipid antibodies (APAs) are developed antibodies to the phospholipid surfaces or to the proteins binding to phospholipids. Increased PS-expressed red blood cells (RBC) may be a risk factor in APAs development. There were only a few studies reported on APAs in thalassemia, and their associations to PS-expressing microparticles (MPs), remain unknown. The presence of antiphospholipid antibodies (APAs) in pediatric thalassemia patients and their associations with phosphatidylserine (PS)- expressing microparticles (MPs), a previously unexplored relationship, were the aims of this report. We identified that positive APA rates were highest in non-transfusion-dependent thalassemia (NTDT) subjects, followed by transfusion-dependent thalassemia (TDT) subjects and controls (29.5%, 18.2% and 17.9%, respectively). Subgroup analysis demonstrated that positive anti- ?2 glycoprotein I (a?2-GPI)- IgG rates in NTDT subjects were significantly greater than in controls and that the percentage of MPs was also significantly elevated in thalassemia subjects. More specifically, there were significant correlations found between a?2GPI-IgG and anticardiolipin (aCL)-IgM APAs, and MPs. |
| format | Article |
| id | doaj-art-a0ee35dfd3b946f8a5ab63dbef8211e7 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-a0ee35dfd3b946f8a5ab63dbef8211e72025-01-02T09:07:37ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062020-10-0112110.4084/mjhid.2020.071High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with MicroparticlesJitlada Chinsuwan0Phatchanat Klaihmon1Praguywan Kadegasem2Ampaiwan Chuansumrit3Anucha Soisamrong4Kovit Pattanapanyasat5Pakawan Wongwerawattanakoon6Nongnuch Sirachainan 7Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok, Tel: +66 2 201 1749, Fax: +66 2 201 1748Center of Excellence for Flow Cytometry, Department of Research and Development, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok. Tel: +66 2 4192848, Fax: +66 2 4192797Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok, Thailand. Tel: +66 2 201 1749, Fax: +66 2 201 1748Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok, Thailand. Tel: +66 2 201 1749, Fax: +66 2 201 1748Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok. Tel: +66 2 201 1432 Fax: +66 2 201 1439Center of Excellence for Flow Cytometry, Department of Research and Development, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok. Tel: +66 2 4192848, Fax: +66 2 4192797Division of Pediatric Nursing, Nursing Department, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok. Tel: +66 2 201 1749 Fax: +66 2 201 1748Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok. Tel: +66 2 201 1749, Fax: +66 2 201 1748Antiphospholipid antibodies (APAs) are developed antibodies to the phospholipid surfaces or to the proteins binding to phospholipids. Increased PS-expressed red blood cells (RBC) may be a risk factor in APAs development. There were only a few studies reported on APAs in thalassemia, and their associations to PS-expressing microparticles (MPs), remain unknown. The presence of antiphospholipid antibodies (APAs) in pediatric thalassemia patients and their associations with phosphatidylserine (PS)- expressing microparticles (MPs), a previously unexplored relationship, were the aims of this report. We identified that positive APA rates were highest in non-transfusion-dependent thalassemia (NTDT) subjects, followed by transfusion-dependent thalassemia (TDT) subjects and controls (29.5%, 18.2% and 17.9%, respectively). Subgroup analysis demonstrated that positive anti- ?2 glycoprotein I (a?2-GPI)- IgG rates in NTDT subjects were significantly greater than in controls and that the percentage of MPs was also significantly elevated in thalassemia subjects. More specifically, there were significant correlations found between a?2GPI-IgG and anticardiolipin (aCL)-IgM APAs, and MPs.http://www.mjhid.org/index.php/mjhid/article/view/4286Thalassemia disease; Antiphospholipid antibody; Microparticles |
| spellingShingle | Jitlada Chinsuwan Phatchanat Klaihmon Praguywan Kadegasem Ampaiwan Chuansumrit Anucha Soisamrong Kovit Pattanapanyasat Pakawan Wongwerawattanakoon Nongnuch Sirachainan High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles Mediterranean Journal of Hematology and Infectious Diseases Thalassemia disease; Antiphospholipid antibody; Microparticles |
| title | High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles |
| title_full | High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles |
| title_fullStr | High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles |
| title_full_unstemmed | High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles |
| title_short | High Prevalence of Antiphospholipid Antibodies in Children with Non-Transfusion Dependent Thalassemia and Possible Correlations with Microparticles |
| title_sort | high prevalence of antiphospholipid antibodies in children with non transfusion dependent thalassemia and possible correlations with microparticles |
| topic | Thalassemia disease; Antiphospholipid antibody; Microparticles |
| url | http://www.mjhid.org/index.php/mjhid/article/view/4286 |
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